In March 2023, the Promise Institute for Human Rights (Promise Institute), together with the Bringing Human Rights Home Network and the UCLA Journal of International Law and Foreign Affairs, convened its Annual Symposium on “Bringing Human Rights Home: Bridging the gap between the international and domestic frames for human rights in the United States.” The Symposium was one part of the Promise Institute’s week-long “Reimagining Rights in the Americas Conference”, which was held in conjunction with the 186th period of sessions of the Inter-American Commission on Human Rights (IACHR or the Commission) at UCLA from March 1 to 11, 2023. This introductory article has two objectives: first, to report on the activities of and outline the key themes arising from the Conference; and second, to outline how our work at the Promise Institute engages critically with the human rights frame and explores how it could be reimagined towards transformative ends, particularly in the Americas. This article is intended to supplement the rich engagement with the human rights frame and IACHR included in the other articles in this Symposium Issue.