IN625 Ni-based metal matrix composites (MMCs) components were deposited using Laser Engineered Net-Shaping (LENS) with Ni-coated and uncoated TiC reinforcement particles to provide insight into the influence of interfaces on MMCs. The microstructures and spatial distribution of TiC particles in the deposited MMCs were characterized, and the mechanical responses were investigated. The results demonstrate that the flowability of the mixed powders, the integrity of the interface between the matrix and the TiC particles, the interaction between the laser beam and the TiC ceramic particles, and the mechanical properties of the LENS-deposited MMCs were all effectively improved by using Ni-coated TiC particles.