Rodent control in the Netherlands is carried out by local authorities, extermination companies or the owners of infested premises. The control of the house mouse, especially in food-handling establishments, is a problem that has existed for some years. Testing in the laboratory indicates a warfarin resistance although the application of new rodenticides like bromadiolone, calciferol and difenacoum has given good results. A "manual" for the control of suspected warfarin resistant house mice is given.