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Scholarly Works (2 results)

Article
Peer Reviewed

Evolution of enzymatic activities in the enolase superfamily: Galactarate dehydratase III from agrobacterium tumefaciens C58

Jacobson, Matthew;
Groninger-Poe, FP;
Bouvier, JT;
Vetting, MW;
Kalyanaraman, C;
Kumar, R;
Almo, SC;
Jacobson, MP;
Gerlt, JA

UC San Francisco Previously Published Works (2014)

The genome of Agrobacterium tumefaciens C58 encodes 12 members of the enolase superfamily (ENS), eight of which are members of the mandelate racemase (MR) subgroup and, therefore, likely to be acid sugar dehydratases. Using a library of 77 acid sugars for

Article
Peer Reviewed

Experimental strategies for functional annotation and metabolism discovery: Targeted screening of solute binding proteins and unbiased panning of metabolomes

Jacobson, Matthew;
Vetting, MW;
Al-Obaidi, N;
Zhao, S;
San, B;
Kim, J;
Wichelecki, DJ;
Bouvier, JT;
Solbiati, JO;
Vu, H;
Zhang, X

UC San Francisco Previously Published Works (2015)

© 2014 American Chemical Society.The rate at which genome sequencing data is accruing demands enhanced methods for functional annotation and metabolism discovery. Solute binding proteins (SBPs) facilitate the transport of the first reactant in a metabolic