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Scholarly Works (1 results)

Article
Peer Reviewed

Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis.

Farese, Robert;
Sajan, MP;
Jurzak, MJ;
Samuels, VT;
Shulman, GI;
Braun, U;
Leitges, M;
Farese, RV

UC San Francisco Previously Published Works (2014)

Tissue-specific knockout (KO) of atypical protein kinase C-λ (PKC-λ) impairs insulin-stimulated glucose transport in muscle (M) and lipid synthesis in liver (L), thereby producing insulin resistance in MλKO mice and insulin-hypersensitivity in LλKO mice. H