A reinforced concrete frame with rocking spine system is evaluated using reliability-index method with main objective of establishing the load and resistance factors for the force-controlled components. A nonlinear structural model of a six-bay six-story concrete frame building with stiff infill panels idealized as compression only struts was constructed in OpenSees. Spine-infills, spine-beams, and spine-columns, are considered as force-controlled components, while non-spine infills and adjacent beams are considered as deformation-controlled components. The model is evaluated with 44 ground motions through Incremental Dynamic Analysis (IDA) to determine the demands in the force-controlled components. The model was also evaluated through response spectrum analysis to define the system’s yield modification factor, , which is used along with hazard curve to obtain the reliability index of the system, . The capacity,,and demand,factors are calculated by defining the probability of demand surpassing capacity in 50 years equal to 0.05%, 0.1%, 0.2%, 0.5%, and 1%. The results show that the decreases as and increases. The capacity and demand factors of spine-infill struts, spine-beams, and spine-columns for 0.1% P(D>C)50 years are: ;; ; respectively.