Here we examined whether one’s perceptual style in viewing own- and other-race faces is associated with performance and bias in social categorization by race, and whether mask use modulates the perceptual style and social categorization effects. We found that Asian participants who adopted more eyes-focused eye movement patterns when viewing Asian faces had a larger bias to judge 50% Asian-Caucasian face morphs as Asian. However, although mask use made participants’ viewing pattern more eyes-focused, it did not change this bias in judging morphed faces, or other-race advantage in social categorization speed. These results suggest that information from the eye region may be sufficient to induce these social categorization effects, and that transient perceptual input change due to mask use does not modulate these social categorization effects. Thus, effects and biases in social categorization may be impervious to mask use. These findings have important implications for social interaction during the pandemic.

Rab11 family interacting protein 4 (Rab11-FIP4) regulates endocytic trafficking. A possible role for Rab11-FIP4 in the regulation of lysosomal function has been proposed, but its precise function in the regulation of cellular homeostasis is unknown. By mRNA array and protein analysis, we found that Rab11-FIP4 is downregulated in the lysosomal storage disease cystinosis, which is caused by genetic defects in the lysosomal cystine transporter, cystinosin. Rescue of Rab11-FIP4 expression in Ctns^-/- fibroblasts re-established normal autophagosome levels and decreased LC3B-II expression in cystinotic cells. Furthermore, Rab11-FIP4 reconstitution increased the localization of the chaperone-mediated autophagy receptor LAMP2A at the lysosomal membrane. Treatment with genistein, a phytoestrogen that upregulates macroautophagy, or the CMA activator QX77 (CA77) restored Rab11-FIP4 expression levels in cystinotic cells supporting a cross-regulation between two independent autophagic mechanisms, lysosomal function and Rab11-FIP4. Improved cellular homeostasis in cystinotic cells rescued by Rab11-FIP4 expression correlated with decreased endoplasmic reticulum stress, an effect that was potentiated by Rab11 and partially blocked by expression of a dominant negative Rab11. Restoring Rab11-FIP4 expression in cystinotic proximal tubule cells increased the localization of the endocytic receptor megalin at the plasma membrane, suggesting that Rab11-FIP4 reconstitution has the potential to improve cellular homeostasis and function in cystinosis.