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Open Access Publications from the University of California

Scholarly Works (3 results)

  • Thesis
  • Peer Reviewed
UCLA Electronic Theses and Dissertations (2020)

In CNN-based text classification tasks, where a CNN model is trained on top of pre-trained word vectors, padding is applied to ensure the input dimension is consistent, which is a requirement for CNN architecture. Traditionally, there are no set rules on how padding should be applied and padding is usually applied to the bottom of the text to achieve uniform length. Borrowing from the idea in computer vision, we show that there is no significant difference between applying zero-padding to the bottom of text embeddings and to both sides of the text embeddings

    Cover page: Empirical Study on the Effect of Zero-Padding in Text Classification with CNN
    • Article
    • Peer Reviewed
    UC Irvine Previously Published Works (2005)
    A collection of 4457 Saccharomyces cerevisiae mutants deleted for nonessential genes was screened for mutants with increased or decreased mobilization of the gypsylike retroelement Ty3. Of these, 64 exhibited increased and 66 decreased Ty3 transposition compared with the parental strain. Genes identified in this screen were grouped according to function by using GOnet software developed as part of this study. Gene clusters were related to chromatin and transcript elongation, translation and cytoplasmic RNA processing, vesicular trafficking, nuclear transport, and DNA maintenance. Sixty-six of the mutants were tested for Ty3 proteins and cDNA. Ty3 cDNA and transposition were increased in mutants affected in nuclear pore biogenesis and in a subset of mutants lacking proteins that interact physically or genetically with a replication clamp loader. Our results suggest that nuclear entry is linked mechanistically to Ty3 cDNA synthesis but that host replication factors antagonize Ty3 replication. Some of the factors we identified have been previously shown to affect Ty1 transposition and others to affect retroviral budding. Host factors, such as these, shared by distantly related Ty retroelements and retroviruses are novel candidates for antiviral targets.
      Cover page: Retroviruses and yeast retrotransposons use overlapping sets of host genesCreative Commons 'BY' version 4.0 license
      • Article
      • Peer Reviewed
      UC San Francisco Previously Published Works (2019)

      Objectives

      To make recommendations on improving understanding of bleeding and thrombosis with pediatric extracorporeal life support including future research directions.

      Data sources

      Evaluation of literature and consensus conferences of pediatric critical care and extracorporeal life support experts.

      Study selection

      A team of 10 experts with pediatric cardiac and extracorporeal membrane oxygenation experience and expertise met through the Pediatric Cardiac Intensive Care Society to review current knowledge and make recommendations for future research to establish "best practice" for anticoagulation management related to extracorporeal life support.

      Data extraction/data synthesis

      This white paper focuses on clinical understanding and limitations of current strategies to monitor anticoagulation. For each test of anticoagulation, limitations of current knowledge are addressed and future research directions suggested.

      Conclusions

      No consensus on best practice for anticoagulation monitoring exists. Structured scientific evaluation to answer questions regarding anticoagulation monitoring and bleeding and thrombotic events should occur in multicenter studies using standardized approaches and well-defined endpoints. Outcomes related to need for component change, blood product administration, healthcare outcome, and economic assessment should be incorporated into studies. All centers should report data on patient receiving extracorporeal life support to a registry.
        Cover page: Bleeding and Thrombosis With Pediatric Extracorporeal Life Support: A Roadmap for Management, Research, and the Future From the Pediatric Cardiac Intensive Care Society: Part 2.
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