In 2020, China eliminated absolute poverty, one of the UN 2030 Agenda for Sustainable Development Goals (SDGs). Guizhou, a historically low GDP province, has been recognized as a successful case under the Chinese government’s poverty alleviation initiative in the big data era. Guizhou demonstrates how the Chinese government piloted an innovative, industry-led, eco-friendly agenda for targeted poverty alleviation. In this chapter, we start by outlining a pilot poverty alleviation model aligning with the Chinese government’s 14th Five-Year Plan (2021-2025). Then we illustrate the blueprint for Guizhou as the first pilot area (“Guizhou Poverty Alleviation Cloud") to break the information and logistic barriers between the economic, housing, education, and health departments, nationally and internationally. We use a community-driven, grassroots case study of Anlong village in Guizhou to describe how the innovation of social media, technology, eco-friendly products (i.e., Shihu,), and locally owned small business has built up a sustainable poverty alleviation system. We finish the discussion with the hope of shedding light on future innovation in poverty alleviation initiatives that integrate the implementation of multiple UN SDGs. In particular, we propose integrating the “Social +" infrastructure into the existing poverty alleviation model.