Limited access to healthcare is a symptom of poverty worldwide. In Knights Landing, California, USA, an economically underserved, agricultural community, advocates recognized that integration of human and animal healthcare could provide a less intimidating gateway to services and facilitate assessments of individuals' health, not just in moments in time, but within the context of the complex interactions with other humans, animals, and their encompassing environment. Humans and animals share diseases resulting from common exposure to environmental pollutants and disease hosts and lack of adequate nutrition. Thus, a One Health-based clinic was established using an interdisciplinary approach to individual and community health. Interprofessional proximity allows veterinarians and physicians to help each other develop the full community-health picture, allowing sentinel cases to come to the forefront. With a collaborative One Health approach and clinicians adaptable to the changing needs of the population, the provision of community-centered healthcare has become more tenable.