We re-derive the renormalization group equation for the effective coupling of the dimension five operator which corresponds to a Majorana mass matrix for the Standard Model neutrinos. We find a result which differs somewhat from earlier calculations, leading to modifications in the evolution of leptonic mixing angles and CP phases. We also present a general method for calculating β-functions from counterterms in MS-like renormalization schemes, which works for tensorial quantities. © 2001 Elsevier Science B.V. All rights reserved.

In a recent re-analysis of the Standard Model (SM) (β)-function for the effective neutrino mass operator, we found that the previous results were not entirely correct. Therefore, we consider the analogous dimension five operators in a class of two Higgs doublet models (2HDM's) and the minimal supersymmetric Standard Model (MSSM). Deriving the renormalization group equations for these effective operators, we confirm the existing result in the case of the MSSM. Some of our 2HDM results are new, while others differ from earlier calculations. This leads to modifications in the renormalization group evolution of leptonic mixing angles and CP phases in the 2HDM's. © 2002 Elsevier Science B.V. All rights reserved.

Introduction

Immunoassays and liquid chromatography-tandem mass spectrometry assays are commonly employed in clinical laboratories for measurement of total testosterone in serum. Results obtained from either of these methodologies compare poorly due to differences in calibration and/or inadvertent detection of interfering substances by the immunoassays. Standardization efforts are underway, but recent studies indicate that accuracy remains an issue.

Methods

This study compares the results from four independently developed and validated LC-MS/MS assays for total testosterone. The calibration for each assay was verified using National Institute of Standards and Technology Standard Reference Material 971.

Results

Initially, one of the four assays had a mean percent difference of +11.44%, compared to the All Method Mean, but following re-verification of all five non-zero calibrator concentrations with the NIST SRM 971, the mean percent difference decreased to -4.88%. Subsequently, the agreement between all four assays showed a mean bias of <5% across the range of all testosterone concentrations (0.13-38.10 nmol/L; 3.7-1098 ng/dL), including at low concentrations of <1 nmol/L (<29 ng/dL).

Conclusions

Excellent agreement between four independently developed LC-MS/MS assays demonstrates that harmonization using standard reference material is attainable. However, as we found in this study, to ensure accurate calibration it is critical to validate the concentrations of new lots of calibrators.

Disease can play an important role in structuring species communities because the effects of disease vary among hosts; some species are driven towards extinction, while others suffer relatively little impact. Why disease impacts vary among host species remains poorly understood for most multi-host pathogens, and factors allowing less-susceptible species to persist could be useful in conserving highly affected species. White-nose syndrome (WNS), an emerging fungal disease of bats, has decimated some species while sympatric and closely related species have experienced little effect. We analysed data on infection prevalence, fungal loads and environmental factors to determine how variation in infection among sympatric host species influenced the severity of WNS population impacts. Intense transmission resulted in almost uniformly high prevalence in all species. By contrast, fungal loads varied over 3 orders of magnitude among species, and explained 98% of the variation among species in disease impacts. Fungal loads increased with hibernating roosting temperatures, with bats roosting at warmer temperatures having higher fungal loads and suffering greater WNS impacts. We also found evidence of a threshold fungal load, above which the probability of mortality may increase sharply, and this threshold was similar for multiple species. This study demonstrates how differences in behavioural traits among species-in this case microclimate preferences-that may have been previously adaptive can be deleterious after the introduction of a new pathogen. Management to reduce pathogen loads rather than exposure may be an effective way of reducing disease impact and preventing species extinctions.This article is part of the themed issue Tackling emerging fungal threats to animal health, food security and ecosystem resilience.

A cDNA clone encoding a portion of Drosophila nuclear lamins Dm1 and Dm2 has been identified by screening a lambda-gt11 cDNA expression library using Drosophila lamin-specific monoclonal antibodies. Two different developmentally regulated mRNA species were identified by Northern blot analysis using the initial cDNA as a probe, and full-length cDNA clones, apparently corresponding to each message, have been isolated. In vitro transcription of both full-length cDNA clones in a pT7 transcription vector followed by in vitro translation in wheat germ lysate suggests that both clones encode lamin Dm0, the polypeptide precursor of lamins Dm1 and Dm2. Nucleotide sequence analyses confirm the impression that both cDNA clones code for the identical polypeptide, which is highly homologous with human lamins A and C as well as with mammalian intermediate filament proteins. The two clones differ in their 3'-untranslated regions. In situ hybridization of lamin cDNA clones to Drosophila polytene chromosomes shows only a single locus of hybridization at or near position 25F on the left arm of chromosome 2. Southern blot analyses of genomic DNA are consistent with the notion that a single or only a few highly similar genes encoding Drosophila nuclear lamin Dm0 exist in the genome.

Gas Technology Institute (GTI), together with its partners University of California at Merced (UC Merced) and MicroLink Devices Inc. (MicroLink) are developing a full spectrum solar energy collection system to deliver variable electricity and on-demand heat. The technology uses secondary optics in a solar receiver to achieve high efficiency at high temperature, collects heat in particles for low fire danger, stores heat in particles instead of molten salt for low cost, and uses double junction (2J) photovoltaic (PV) cells with backside infrared (IR) reflectors on the secondary optical element to raise exergy efficiency. The overall goal is to deliver enhancement to established trough technology while exceeding the heliostat power tower molten salt temperature limit. The use of inert particles for heat transfer may make parabolic troughs safer near population centers and may be valuable for industrial facilities.