In this paper, we discuss the feasibility and the performance assessment of a possible MCAO system for E-ELT, basedon the novel concept of Global MCAO, which takes advantage of a very wide technical FoV to perform adaptive opticscorrection using only natural guide stars, with the aim to increase the sky coverage. The technique envisages thedefinition of Virtual-DMs, as tools for the global reconstruction. This investigation has been carried out during afeasibility study we performed for ESO, in which we combined computations, simulations and literature. The aim of thisanalysis is to identify and review the main parameters and the technical issues, which would act as error sources in a realGMCAO system, evaluating their contribution to the overall performance. The study involves both issues related to thePyramid WFS in general, and to the GMCAO case in particular, including the wavelength and FoV size selection, thenumber of guide stars and reconstructed Virtual-DMs, and actual components parameters.