Stereotactic radiation approaches are gaining more popularity for the treatment of intracranial as well as extracranial tumors in organs such as the liver and lung. Technology, rather than biology, is driving the rapid adoption of stereotactic body radiation therapy (SBRT), also known as stereotactic ablative radiotherapy (SABR), in the clinic due to advances in precise positioning and targeting. Dramatic improvements in tumor control have been demonstrated; however, our knowledge of normal tissue biology response mechanisms to large fraction sizes is lacking. Herein, we will discuss how SABR can induce cellular expression of MHC I, adhesion molecules, costimulatory molecules, heat shock proteins, inflammatory mediators, immunomodulatory cytokines, and death receptors to enhance antitumor immune responses.

The spatial fluctuations of the extragalactic background light trace the total emission from all stars and galaxies in the Universe. A multiwavelength study can be used to measure the integrated emission from first galaxies during reionization when the Universe was about 500 million years old. Here we report arcmin-scale spatial fluctuations in one of the deepest sky surveys with the Hubble Space Telescope in five wavebands between 0.6 and 1.6 μm. We model-fit the angular power spectra of intensity fluctuation measurements to find the ultraviolet luminosity density of galaxies at redshifts greater than 8 to be log ρ(UV) = 27.4(+0.2)(-1.2) ergs(-1) Hz(-1) Mpc(-3) (1σ). This level of integrated light emission allows for a significant surface density of fainter primeval galaxies that are below the point-source detection level in current surveys.

The epoch of reionization (6 < z < 10) marks the period in our universe when the first large galaxies grew to fruition, and began to affect the universe around them. Massive stars, and potentially accreting supermassive black holes, filled the universe with ionizing radiation, burning off the haze of neutral gas that had filled the intergalactic medium (IGM) since recombination (z~1000). The evolution of this process constrains key properties of these earliest luminous sources, thus observationally constraining reionization is a key science goal for the next decade. The measurement of Lyman-alpha emission from photometrically-identified galaxies is a highly constraining probe of reionization, as a neutral IGM will resonantly scatter these photons, reducing detectability. While significant work has been done with 8-10m telescopes, these observations require extremely large telescopes (ELTs); the flux limits available from today's 10m class telescopes are sufficient for only the brightest known galaxies (m < 26). Ultra-deep surveys with the Giant Magellan Telescope (GMT) and Thirty Meter Telescope (TMT) will be capable of detecting Lyman-alpha emission from galaxies 2-3 magnitudes fainter than today's deepest surveys. Wide-field fiber spectroscopy on the GMT combined with narrow-field AO-assisted slit spectroscopy on the TMT will be able to probe the expected size of ionized bubbles throughout the epoch of reionization, following up degree scale deep imaging surveys with the Wide Field Infrared Space Telescope. These data will provide the first resolved Lyman-alpha-based maps of the ionized intergalactic medium throughout the epoch of reionization, constraining models of both the temporal and spatial evolution of this phase change.

Improved understanding of soft-tissue sarcoma (STS) biology has led to better distinction and subtyping of these diseases with the hope of exploiting the molecular characteristics of each subtype to develop appropriately targeted treatment regimens. In the care of patients with extremity STS, adjunctive radiation therapy (RT) is used to facilitate limb and function, preserving surgeries while maintaining five-year local control above 85%. In contrast, for STS originating from nonextremity anatomical sites, the rate of local recurrence is much higher (five-year local control is approximately 50%) and a major cause of death and morbidity in these patients. Incorporating novel technological advancements to administer accurate RT in combination with novel radiosensitizing agents could potentially improve local control and overall survival. RT efficacy in STS can be increased by modulating biological pathways such as angiogenesis, cell cycle regulation, cell survival signaling, and cancer-host immune interactions. Previous experiences, advancements, ongoing research, and current clinical trials combining RT with agents modulating one or more of the above pathways are reviewed. The standard clinical management of patients with STS with pretreatment biopsy, neoadjuvant treatment, and primary surgery provides an opportune disease model for interrogating translational hypotheses. The purpose of this review is to outline a strategic vision for clinical translation of preclinical findings and to identify appropriate targeted agents to combine with radiotherapy in the treatment of STS from different sites and/or different histology subtypes.

We present a new measurement of the gas-phase mass-metallicity relation (MZR) and its dependence on star formation rates (SFRs) at 1.3 < z < 2.3. Our sample comprises 1056 galaxies with a mean redshift of z = 1.9, identified from the Hubble Space Telescope Wide Field Camera 3 (WFC3) grism spectroscopy in the Cosmic Assembly Near-infrared Deep Extragalactic Survey and the WFC3 Infrared Spectroscopic Parallel Survey. This sample is four times larger than previous metallicity surveys at z ~ 2 and reaches an order of magnitude lower in stellar mass (108 M o?). Using stacked spectra, we find that the MZR evolves by 0.3 dex relative to z ~ 0.1. Additionally, we identify a subset of 49 galaxies with high signal-to-noise (S/N) spectra and redshifts between 1.3 < z < 1.5, where Ha emission is observed along with [O iii] and [O ii]. With accurate measurements of SFR in these objects, we confirm the existence of a mass-metallicity-SFR (M-Z-SFR) relation at high redshifts. These galaxies show systematic differences from the local M-Z-SFR relation, which vary depending on the adopted measurement of the local relation. However, it remains difficult to ascertain whether these differences could be due to redshift evolution, as the local M-Z-SFR relation is poorly constrained at the masses and SFRs of our sample. Lastly, we reproduced our sample selection in the IllustrisTNG hydrodynamical simulation, demonstrating that our line flux limit lowers the normalization of the simulated MZR by 0.2 dex. We show that the M-Z-SFR relation in IllustrisTNG has an SFR dependence that is too steep by a factor of around 3.

The majority of massive disk galaxies in the local Universe show a stellar barred structure in their central regions, including our Milky Way1,2. Bars are supposed to develop in dynamically cold stellar disks at low redshift, as the strong gas turbulence typical of disk galaxies at high redshift suppresses or delays bar formation3,4. Moreover, simulations predict bars to be almost absent beyond z = 1.5 in the progenitors of Milky Way-like galaxies5,6. Here we report observations of ceers-2112, a barred spiral galaxy at redshift zphot ≈ 3, which was already mature when the Universe was only 2 Gyr old. The stellar mass (M★ = 3.9 × 109 M⊙) and barred morphology mean that ceers-2112 can be considered a progenitor of the Milky Way7-9, in terms of both structure and mass-assembly history in the first 2 Gyr of the Universe, and was the closest in mass in the first 4 Gyr. We infer that baryons in galaxies could have already dominated over dark matter at z ≈ 3, that high-redshift bars could form in approximately 400 Myr and that dynamically cold stellar disks could have been in place by redshift z = 4-5 (more than 12 Gyrs ago)10,11.

Context. We investigate the morphology and resolved physical properties of a sample of 22 IR-selected dusty star-forming galaxies at cosmic noon using the James Webb Space Telescope NIRCam images obtained in the EGS field for the CEERS survey. The exceptional resolution of the NIRCam images allowed us to spatially resolve these galaxies up to 4.4 µm and identify their bulge or core even when very extinguished by dust. Aims. The goal of this study is to obtain a better understanding of the formation and evolution of FIR-bright galaxies by spatially resolving their properties using JWST in order to look through the dust and bridge the gap between the compact FIR sources and the larger optical star-forming galaxies. Methods. Based on red-green-blue images from the F115W, F200W, and F444W filters, we divided each galaxy into several uniformly colored regions, fit their respective SEDs, and measured physical properties. After classifying each region as star forming or quiescent, we assigned galaxies to three classes depending on whether active star formation is located in the core, in the disk, or in both. Results. (i) We find that the galaxies at a higher redshift tend to have a fragmented disk with a low core mass fraction. They are at an early stage of bulge formation. When moving toward a lower redshift, the core mass fraction increases, and the bulge growth is associated with a stabilization of the disk, which translates into less patches and clumps. The NIRCam data clearly point toward bulge formation in preexisting disks. (ii) Lopsidedness is a very common feature of DSFGs. It has been wrongly overlooked for a long time and could have a major impact on the evolution of DSFGs. (iii) Twenty-three percent of the galaxies have a star-forming core embedded in a quiescent disk. They seem to be undergoing outside-in quenching, often facilitated by their strong lopsidedness inducing instabilities. (iv) We show that half of our galaxies with star formation concentrated in their core are good sub-millimeter galaxy near-IR counterpart candidates, demonstrating that compact SMGs are usually surrounded by a larger, less obscured disk. (v) Finally, we found surprising evidence for clump-like substructures being quiescent or residing in quiescent regions. Conclusions. This work demonstrates the major impact JWST/NIRCam has on understanding the complexity of the evolution of distant massive galaxies regarding bulge formation and quenching mechanisms.

We report the discovery of 15 exceptionally luminous 10 ≲ z ≲ 14 candidate galaxies discovered in the first 0.28 deg2 of JWST/NIRCam imaging from the COSMOS-Web survey. These sources span rest-frame UV magnitudes of −20.5 > M UV > −22, and thus constitute the most intrinsically luminous z ≳ 10 candidates identified by JWST to date. Selected via NIRCam imaging, deep ground-based observations corroborate their detection and help significantly constrain their photometric redshifts. We analyze their spectral energy distributions using multiple open-source codes and evaluate the probability of low-redshift solutions; we conclude that 12/15 (80%) are likely genuine z ≳ 10 sources and 3/15 (20%) likely low-redshift contaminants. Three of our z ∼ 12 candidates push the limits of early stellar mass assembly: they have estimated stellar masses ∼ 5 × 109 M ⊙, implying an effective stellar baryon fraction of ϵ ⋆ ∼ 0.2−0.5, where ϵ ⋆ ≡ M ⋆/(f b M halo). The assembly of such stellar reservoirs is made possible due to rapid, burst-driven star formation on timescales < 100 Myr where the star formation rate may far outpace the growth of the underlying dark matter halos. This is supported by the similar volume densities inferred for M ⋆ ∼ 1010 M ⊙ galaxies relative to M ⋆ ∼ 109 M ⊙—both about 10−6 Mpc−3—implying they live in halos of comparable mass. At such high redshifts, the duty cycle for starbursts would be of order unity, which could cause the observed change in the shape of the UV luminosity function from a double power law to a Schechter function at z ≈ 8. Spectroscopic redshift confirmation and ensuing constraints of their masses will be critical to understand how, and if, such early massive galaxies push the limits of galaxy formation in the Lambda cold dark matter paradigm.

We present the first publicly released catalog of sources obtained from the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX). HETDEX is an integral field spectroscopic survey designed to measure the Hubble expansion parameter and angular diameter distance at 1.88 < z < 3.52 by using the spatial distribution of more than a million Lyα-emitting galaxies over a total target area of 540 deg2. The catalog comes from contiguous fiber spectra coverage of 25 deg2 of sky from 2017 January through 2020 June, where object detection is performed through two complementary detection methods: one designed to search for line emission and the other a search for continuum emission. The HETDEX public release catalog is dominated by emission-line galaxies and includes 51,863 Lyα-emitting galaxy (LAE) identifications and 123,891 [O ii]-emitting galaxies at z < 0.5. Also included in the catalog are 37,916 stars, 5274 low-redshift (z < 0.5) galaxies without emission lines, and 4976 active galactic nuclei. The catalog provides sky coordinates, redshifts, line identifications, classification information, line fluxes, [O ii] and Lyα line luminosities where applicable, and spectra for all identified sources processed by the HETDEX detection pipeline. Extensive testing demonstrates that HETDEX redshifts agree to within Δz < 0.02, 96.1% of the time to those in external spectroscopic catalogs. We measure the photometric counterpart fraction in deep ancillary Hyper Suprime-Cam imaging and find that only 55.5% of the LAE sample has an r-band continuum counterpart down to a limiting magnitude of r ∼ 26.2 mag (AB) indicating that an LAE search of similar sensitivity to HETDEX with photometric preselection would miss nearly half of the HETDEX LAE catalog sample. Data access and details about the catalog can be found online at http://hetdex.org/. A copy of the catalogs presented in this work (Version 3.2) is available to download at Zenodo doi:10.5281/zenodo.7448504.

We test the relationship between UV-derived star formation rates (SFRs) and the 7.7 μm polycyclic aromatic hydrocarbon luminosities from the integrated emission of galaxies at z ∼ 0-2. We utilize multiband photometry covering 0.2-160 μm from the Hubble Space Telescope, CFHT, JWST, Spitzer, and Herschel for galaxies in the Cosmic Evolution Early Release Science (CEERS) Survey. We perform spectral energy distribution (SED) modeling of these data to measure dust-corrected far-UV (FUV) luminosities, L FUV, and UV-derived SFRs. We then fit SED models to the JWST/MIRI 7.7-21 μm CEERS data to derive rest-frame 7.7 μm luminosities, L 770, using the average flux density in the rest-frame MIRI F770W bandpass. We observe a correlation between L 770 and L FUV, where log L 770 ∝ ( 1.27 ± 0.04 ) log L FUV . L 770 diverges from this relation for galaxies at lower metallicities, lower dust obscuration, and for galaxies dominated by evolved stellar populations. We derive a “single-wavelength” SFR calibration for L 770 that has a scatter from model estimated SFRs (σ ΔSFR) of 0.24 dex. We derive a “multiwavelength” calibration for the linear combination of the observed FUV luminosity (uncorrected for dust) and the rest-frame 7.7 μm luminosity, which has a scatter of σ ΔSFR = 0.21 dex. The relatively small decrease in σ suggests this is near the systematic accuracy of the total SFRs using either calibration. These results demonstrate that the rest-frame 7.7 μm emission constrained by JWST/MIRI is a tracer of the SFR for distant galaxies to this accuracy, provided the galaxies are dominated by star formation with moderate-to-high levels of attenuation and metallicity.