The effect of fuel composition on performance is evaluated on a model gas turbine combustor designed to mimic key features of practical devices. A flexible fuel injection system is utilized to control the placement of the fuel in the device to allow exploration and evaluation of fuel distribution effects in addition to chemistry effects. Gas blends reflecting the extremes in compositions found in the U.S. are considered. The results illustrate that, for the conditions and configuration studied, both fuel chemistry and fuel air mixing play a role in the performance of the device. While chemistry appears to be the predominant factor in stability, a role is noted in emissions performance as well. It is also found that changes in fuel distribution associated with changes in fuel momentum for fixed firing rate also have an impact on emissions. For the system considered, a strategy for sustaining optimal performance while fuel composition changes is illustrated.