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Scholarly Works (2 results)

Article
Peer Reviewed

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.

Passegue, Emmanuelle;
Pietras, EM;
Lakshminarasimhan, R;
Techner, J-M;
Fong, S;
Flach, J;
Binnewies, M;
Passegué, E

UC San Francisco Previously Published Works (2014)

Type I interferons (IFN-1s) are antiviral cytokines that suppress blood production while paradoxically inducing hematopoietic stem cell (HSC) proliferation. Here, we clarify the relationship between the proliferative and suppressive effects of IFN-1s on HS

Article
Peer Reviewed

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.

Passegue, Emmanuelle;
Pietras, EM;
Mirantes-Barbeito, C;
Fong, S;
Loeffler, D;
Kovtonyuk, LV;
Zhang, S;
Lakshminarasimhan, R;
Chin, CP;
Techner, J-M;
Will, B

UC San Francisco Previously Published Works (2016)

Haematopoietic stem cells (HSCs) maintain lifelong blood production and increase blood cell numbers in response to chronic and acute injury. However, the mechanism(s) by which inflammatory insults are communicated to HSCs and their consequences for HSC act