A comprehensive review of herpes virus drug discovery with an emphasis on the most recent advances in the field and their progression from early discovery to clinical development is presented. Small molecules against multiple herpes viruses with targets th

Herpesviruses rely on a homodimeric protease for viral capsid maturation. A small molecule, DD2, previously shown to disrupt dimerization of Kaposis sarcoma-associated herpesvirus protease (KSHV Pr) by trapping an inactive monomeric conformation and two an