This report presents the findings of a study of commercial motor vehicle inspection and screening station practices with a focus on the use of various technologies to help address problems related to safety, security, roadway infrastructure, and air quality. A review of industry literature identified the various types of inspection and screening practices that have been and are being implemented including weight and size management, on-board equipment checking, driver-related violations and cargo monitoring, credential checking, and exhaust emissions monitoring. The review also identified technologies that have been employed as part of these practices as well as an assessment of their performance. The research also involved the use of a survey of State and Provincial Departments of Transportation in North America that have implemented specific practices. Survey findings indicate that to a certain degree a more integrated and multi-practice approach is being taken; a wide array of technologies is in use; and, technology evaluations show they have generally performed well.