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Open Access Publications from the University of California

Scholarly Works (4 results)

  • Article
  • Peer Reviewed
Dermatology Online Journal, Volume 30, Issue 1 (2024)
    Cover page: Three cases of Anti-MDA5 positive dermatomyositis with interstitial lung disease and pneumomediastiumCreative Commons 'BY-NC-ND' version 4.0 license
    • Article
    • Peer Reviewed
    Dermatology Online Journal, Volume 22, Issue 4 (2016)
    Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease. LABD is considered mostly idiopathic, butsome cases have been reported to be drug-induced, mainly associated with vancomycin (VCM).We present two cases of LABD possibly associated with VCM used for cardiac surgery prophylaxis; in the presented cases, the eruptions occurred only after VCM withdrawal, therefore leaving a question about the relationship between VCM and LABD in these cases.We reviewed previous reports of VCM-induced LABD and analyzed the following parameters: gender, age, recent medical history, concurrent medication, latency period, progression after withdrawal, time to resolution, treatment, and rechallenge.Results: The causal relationship between VCM and LABD was often unclear; patients frequently had concurrent medication and symptoms frequently began and/or progressed after VCM withdrawal. Among the 46 reviewed patients in addition to our two cases (n=48), 20 (42%) had recent history of cardiac procedure, cardiac infection, congestive heart failure, or aortic aneurism.Conclusion: Further investigation is needed to ascertain the association between LABD, VCM, and heart disease.
      Cover page: Vancomycin-induced linear IgA bullous dermatosis: associationsCreative Commons 'BY-NC-ND' version 4.0 license
      • Article
      • Peer Reviewed
      Dermatology Online Journal, Volume 16, Issue 3 (2010)
        • Article
        • Peer Reviewed
        Dermatology Online Journal, Volume 23, Issue 2 (2017)

        A 4-month-old infant was observed with an acute itchy bullous dermatosis, predominantly involving the extremities, which revealed a dermal infiltrate rich in eosinophils, C3 deposits at the dermalepidermal junction, and circulating antibodies to BP180 antigen, confirming the diagnosis of bullous pemphigoid. He was initially treated with deflazacort 1 mg/kg/day, further increased to 2 mg/ kg/day, followed by reduction over seven weeks with complete clinical resolution within this period. We discuss epidemiology, etiology, relationship with vaccination, clinical features, and treatment of thisrelatively rare bullous dermatosis in the pediatric age.

          Cover page: Bullous pemphigoid of infancy – report and review of infantile and pediatric bullous pemphigoidCreative Commons 'BY-NC-ND' version 4.0 license
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