Explaining the observed diversity of supernovae (SNe) and the physics of explosion requires knowledge of their progenitor stars, which can be obtained by constraining the circumstellar medium (CSM). Models of the SN ejecta colliding with the CSM are necessary to infer the structure of the CSM and tie it back to a progenitor model. Recent SNe I revealed CSM concentrated at a distance r ∼ 1016 cm, for which models of SN interaction are extremely limited. In this paper, we assume the concentrated region is a "wall" representing swept-up material, and unswept material lies outside the wall. We simulate one-dimensional hydrodynamics of SNe Ia and Ib impacting 300 unique CSM configurations using RT1D, which captures the Rayleigh-Taylor instability. We find that the density ratio between the wall and ejecta-denoted A 0 or "wall height"-is key, and higher walls deviate more from self-similar evolution. Functional fits accounting for A 0 are presented for the forward-shock radius evolution. We show that higher walls have more degeneracy between CSM properties in the deceleration parameter, slower shocks, deeper-probing reverse shocks, slower shocked ejecta, less ejecta mass than CSM in the shock, and more mixing of ejecta into the CSM at early times. We analyze observations of SN 2014C (Type Ib) and suggest that it had a moderately high wall (10 ≲ A 0 ≲ 200) and wind-like outer CSM. We also postulate an alternate interpretation for the radio data of SN 2014C, that the radio rise occurs in the wind rather than the wall. Finally, we find that hydrodynamic measurements at very late times cannot distinguish the presence of a wall, except perhaps as an anomalously wide shock region.

The optical transient PTF11kx exhibited both the characteristic spectral features of Type Ia supernovae (SNe Ia) and the signature of ejecta interacting with circumstellar material (CSM) containing hydrogen, indicating the presence of a nondegenerate companion. We present an optical spectrum at 1342 days after peak from Keck Observatory, in which the broad component of Hα emission persists with a similar profile as in early-time observations. We also present Spitzer IRAC detections obtained 1237 and 1818 days after peak, and an upper limit from Hubble Space Telescope ultraviolet imaging at 2133 days. We interpret our late-time observations in the context of published results - and reinterpret the early-time observations - in order to constrain the CSM's physical parameters and to compare to theoretical predictions for recurrent-nova systems. We find that the CSM's radial extent may be several times the distance between the star and the CSM's inner edge, and that the CSM column density may be two orders of magnitude lower than previous estimates. We show that the Hα luminosity decline is similar to other SNe with CSM interaction and demonstrate how our infrared photometry is evidence for newly formed, collisionally heated dust. We create a model for PTF11kx's late-time CSM interaction and find that X-ray reprocessing by photoionization and recombination cannot reproduce the observed Hα luminosity, suggesting that the X-rays are thermalized and that Hα radiates from collisional excitation. Finally, we discuss the implications of our results regarding the progenitor scenario and the geometric properties of the CSM for the PTF11kx system.

The nature and role of the binary companion of carbon-oxygen white dwarf stars that explode as Type Ia supernovae (SNe Ia) are not yet fully understood. Past detections of circumstellar material (CSM) that contain hydrogen for a small number of SN Ia progenitor systems suggest that at least some have a nondegenerate companion. In order to constrain the prevalence, location, and quantity of CSM in SN Ia systems, we performed a near-ultraviolet (NUV) survey with the Hubble Space Telescope (HST) to look for the high-energy signature of SN Ia ejecta interacting with the CSM. Our survey revealed that SN 2015cp, an SN 1991T-like overluminous SN Ia, was experiencing late-onset interaction between its ejecta and the surrounding CSM 664 days after its light-curve peak. We present ground- and space-based follow-up observations of SN 2015cp that reveal optical emission lines of H and Ca, typical signatures of ejecta-CSM interaction. We show how SN 2015cp was likely similar to the well-studied SN Ia-CSM event PTF11kx, making it the second case in which an unambiguously classified SN Ia was observed to interact with a distant shell of CSM that contains hydrogen (R CSM 10 16 cm). The remainder of our HST NUV images of SNe Ia were nondetections that we use to constrain the occurrence rate of observable late-onset CSM interaction. We apply theoretical models for the emission from ejecta-CSM interaction to our NUV nondetections and place upper limits on the mass and radial extent of CSM in SN Ia progenitor systems.

Despite their cosmological utility, the progenitors of Type Ia supernovae (SNe Ia) are still unknown, with many efforts focused on whether accretion from a nondegenerate companion can grow a carbon-oxygen white dwarf to near the Chandrasekhar mass. The association of SNe Ia resembling SN 1991T ("91T-like") with circumstellar interaction may be evidence for this "single-degenerate" channel. However, the observed circumstellar medium (CSM) in these interacting systems is unlike a stellar wind - of particular interest, it is sometimes detached from the stellar surface, residing at ∼1016 cm. A Hubble Space Telescope (HST) program to discover detached CSM around 91T-like SNe Ia successfully discovered interaction nearly two years after explosion in SN 2015cp (Graham et al. 2018). In this work, we present radio and X-ray follow-up observations of SN 2015cp and analyze them in the framework of Harris et al. (2016) to limit the properties of a constant-density CSM shell in this system. Assuming the HST detection took place shortly after the shock crossed the CSM, we constrain the total CSM mass in this system to be <0.5 . This limit is comparable to the CSM mass of supernova PTF11kx, but does not rule out lower masses predicted for recurrent novae. From lessons learned modeling PTF11kx and SN 2015cp, we suggest a strategy for future observations of these events to increase the sample of known interacting SNe Ia.

Copyright © 2014 Massachusetts Medical Society. All rights reserved. BACKGROUND In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based γ-retrovirus vector expressing interleukin-2 receptor γ-chain (γc) complementary DNA successfully restored immunity in most patients but resulted in vector-induced leukemia through enhancermediated mutagenesis in 25% of patients. We assessed the efficacy and safety of a self-inactivating retrovirus for the treatment of SCID-X1.METHODS We enrolled nine boys with SCID-X1 in parallel trials in Europe and the United States to evaluate treatment with a self-inactivating (SIN) γ-retrovirus vector containing deletions in viral enhancer sequences expressing γc (SIN-γc).RESULTS All patients received bone marrow-derived CD34+ cells transduced with the SIN-γc vector, without preparative conditioning. After 12.1 to 38.7 months of follow-up, eight of the nine children were still alive. One patient died from an overwhelming adenoviral infection before reconstitution with genetically modified T cells. Of the remaining eight patients, seven had recovery of peripheral-blood T cells that were functional and led to resolution of infections. The patients remained healthy thereafter. The kinetics of CD3+ T-cell recovery was not significantly different from that observed in previous trials. Assessment of insertion sites in peripheral blood from patients in the current trial as compared with those in previous trials revealed significantly less clustering of insertion sites within LMO2, MECOM, and other lymphoid proto-oncogenes in our patients.CONCLUSIONS This modified γ-retrovirus vector was found to retain efficacy in the treatment of SCID-X1. The long-term effect of this therapy on leukemogenesis remains unknown.