This is an account of the forms and semantic dimensions of spatial relations in Manange (Tibeto-Burman, Tamangic; Nepal), with comparison to sister language Nar-Phu. Topological relations (“IN/ON/AT/NEAR”) in these languages are encoded by locative enclitics and also by a set of noun-like objects termed as “locational roots.” In Manange, the general locative enclitic is more frequently encountered for a wide range of topological relations, while in Nar-Phu, the opposite pattern is observed, i.e. more frequent use of locational roots. While the linguistic frame of reference system encoded in these forms is primarily relative (i.e. oriented on the speaker’s own viewing perspective), a more extrinsic/absolute system emerges with certain verbs of motion in these languages, with verbs like “come,” “go,” and certain verbs of placement or posture orienting to arbitrary fixed bearings such as slope. This account also provides some examples of cultural or metaphorical extensions of spatial forms as they are encountered in connected speech.