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Scholarly Works (1 results)

Article
Peer Reviewed

Genotype-dependent efficacy of a Dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas

McCormick, Frank;
Shoji, K;
Oda, K;
Kashiyama, T;
Ikeda, Y;
Nakagawa, S;
Sone, K;
Miyamoto, Y;
Hiraike, H;
Tanikawa, M;
Miyasaka, A

UC San Francisco Previously Published Works (2012)

The PI3K (phosphatidylinositol-3-kinase)/mTOR (mammalian target of rapamycin) pathway is frequently activated in endometrial cancer through various PI3K/AKT-activating genetic alterations. We examined the antitumor effect of NVP-BEZ235-a dual PI3K/mTOR inh