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Open Access Publications from the University of California

Scholarly Works (4 results)

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  • Peer Reviewed
Project HX (2019)

Dear Readers,

Project Hx is a collection of narratives and photographs with a goal to highlight the rich diversity of the medical community. It is a portraiture of people’s stories and backgrounds, their experiences and adventures in healthcare, and ultimately a way to show a human side behind the oftentimes faceless nature of medicine. We aim to document these stories and perspectives in the form of biographical interviews and portrait photography as a way to provide our audience with daily glimpses into the human lives surrounding medicine. The people interviewed portray only a fraction of the countless number of unique attitudes and ideologies that represent the medical community, but we hope that it can serve as kindling for continued conversation. While reading the stories, please keep in mind that narratives are powerful only when they are genuine. They can be genuine only under the climate of acceptance and open-mindedness. Thus, we hope that each story is received free of judgment and prejudice.This year’s fourth issue is particularly personal, as it explores the thoughts and opinions that medical students and healthcare providers have regarding mental health in medicine, and their own personal journey towards finding strength in this profession. Given the intimate nature of this theme, most of our interviewees opted towards anonymity, but we are grateful that they were willing to step forward to reveal their personal struggles, and put a face - though not in the literal sense - on the true reality of mental health challenges that come with the rigorous journey towards becoming a physician.

Sincerely,

Project Hx Team

UC Irvine School of Medicine

Editor-In-Chiefs: Thalia Nguyen, Soe Thein; Design Editor: May Hui

    Cover page: Project Hx: Mental Health MattersCreative Commons 'BY' version 4.0 license
    • Article
    • Peer Reviewed
    UC Irvine Previously Published Works (2020)
    Pneumonectomy after traumatic lung injury (TLI) is associated with shock, increased pulmonary vascular resistance, and eventual right ventricular failure. Historically, trauma pneumonectomy (TP) mortality rates ranged between 53 and 100%. It is unclear if contemporary mortality rates have improved. Therefore, we evaluated outcomes associated with TP and limited lung resections (LLR) (i.e., lobectomy and segmentectomy) and aimed to identify predictors of mortality, hypothesizing that TP is associated with greater mortality versus LLR. We queried the Trauma Quality Improvement Program (2010-2016) and performed a multivariable logistic regression to determine the independent predictors of mortality in TLI patients undergoing TP versus LLR. TLI occurred in 287,276 patients. Of these, 889 required lung resection with 758 (85.3%) undergoing LLR and 131 (14.7%) undergoing TP. Patients undergoing TP had a higher median injury severity score (26.0 vs. 24.5, p = 0.03) but no difference in initial median systolic blood pressure (109 vs. 107 mmHg, p = 0.92) compared to LLR. Mortality was significantly higher for TP compared to LLR (64.9% vs 27.2%, p < 0.001). The strongest independent predictor for mortality was undergoing TP versus LLR (OR 4.89, CI 3.18-7.54, p < 0.001). TP continues to be associated with a higher mortality compared to LLR. Furthermore, TP is independently associated with a fivefold increased risk of mortality compared to LLR. Future investigations should focus on identifying parameters or treatment modalities that improve survivability after TP. We recommend that surgeons reserve TP as a last-resort management given the continued high morbidity and mortality associated with this procedure.
      Cover page: Outcomes after pneumonectomy versus limited lung resection in adults with traumatic lung injury
      • Article
      • Peer Reviewed
      UC Irvine Previously Published Works (2016)
      Although, green tea has numerous health benefits, adverse effects with excessive consumption have been reported. Using Drosophila melanogaster, a decrease in male fertility with green tea was evidenced. Here, the extent of green tea toxicity on development and reproduction was investigated. Drosophila melanogaster embryos and larvae were exposed to various doses of green tea polyphenols (GTP). Larvae exposed to 10 mg/mL GTP were slower to develop, emerged smaller, and exhibited a dramatic decline in the number of emerged offspring. GTP protected flies against desiccation but sensitized them to starvation and heat stress. Female offspring exhibited a decline in reproductive output and decreased survival while males were unaffected. GTP had a negative impact on reproductive organs in both males and females (e.g., atrophic testes in males, absence of mature eggs in females). Collectively, the data show that high doses of GTP adversely affect development and reproduction of Drosophila melanogaster.
        Cover page: The impact of green tea polyphenols on development and reproduction in Drosophila melanogaster
        • Article
        • Peer Reviewed
        UC Irvine Previously Published Works (2016)
        Although, green tea has numerous health benefits, adverse effects with excessive consumption have been reported. Using Drosophila melanogaster, a decrease in male fertility with green tea was evidenced. Here, the extent of green tea toxicity on development and reproduction was investigated. Drosophila melanogaster embryos and larvae were exposed to various doses of green tea polyphenols (GTP). Larvae exposed to 10 mg/mL GTP were slower to develop, emerged smaller, and exhibited a dramatic decline in the number of emerged offspring. GTP protected flies against desiccation but sensitized them to starvation and heat stress. Female offspring exhibited a decline in reproductive output and decreased survival while males were unaffected. GTP had a negative impact on reproductive organs in both males and females (e.g., atrophic testes in males, absence of mature eggs in females). Collectively, the data show that high doses of GTP adversely affect development and reproduction of Drosophila melanogaster.
          Cover page: The impact of green tea polyphenols on development and reproduction in <i>Drosophila melanogaster</i>.Creative Commons 'BY' version 4.0 license
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