Among the sufficiency, efficiency, and renewable frameworks for reducing energy use and energy-related carbon emissions, Building Energy Sufficiency (BES) is gaining attention from policy makers and engineers. Despite the significant role of the building sector in the success of national energy and climate plans, there is a lack of research on the drivers, technologies, and effective policy instruments required to achieve BES in the building operational phase. To fill this gap, this study presents a systematic review of the definition and paradigm of BES and concludes that BES should address both occupant demand and energy or emissions requirements simultaneously. The characteristics of occupant demand in building services are divided into four dimensions: time and space, quality and quantity, control and adjustment, and flexibility. Technical options regarding the building architecture, the envelope system, and the building energy system are reviewed. Finally, policy implications and recommendations are discussed. The multiple benefits and multidisciplinary nature of BES justify further research and accelerated policy implementation in developed and developing countries.

China's Design Standard for Energy Efficiency of Public Buildings (the Design Standard) is widely used in the design phase to regulate the energy efficiency of physical assets (envelope, lighting, HVAC) in buildings. However, the standard does not consider many important factors that influence the actual energy use in buildings, and this can lead to gaps between the design estimates and actual energy consumption. To achieve the national energy savings targets defined in the strategic 12th Five-Year Plan, China developed the first standard for energy consumption of buildings GB/T51161-2016 (the Consumption Standard). This study provides an overview of the Consumption Standard, identifies its strengths and weaknesses, and recommends future improvements. The analysis and discussion of the constraint value and the leading value, two key indicators of the energy use intensity, provide insight into the intent and effectiveness of the Consumption Standard. The results indicated that consistency between China's Design Standard GB 50189-2015 and the Consumption Standard GB/T51161-2016 could be achieved if the Design Standard used the actual building operations and occupant behavior in calculating the energy use in Chinese buildings. The development of an outcome-based code in the U.S. was discussed in comparison with China's Consumption Standard, and this revealed the strengths and challenges associated with implementing a new compliance method based on actual energy use in buildings in the U.S. Overall, this study provides important insights into the latest developments of actual consumption-based building energy standards, and this information should be valuable to building designers and energy policy makers in China and the U.S.

Background

Current diagnosis of hepatitis C virus (HCV) infection requires two sequential steps: testing for anti-HCV followed by HCV RNA PCR to confirm viremia. We have developed a highly sensitive and specific HCV-antigens enzyme immunoassay (HCV-Ags EIA) for one-step diagnosis of viremic HCV infection.

Aim

To assess the clinical application of the HCV-Ags EIA in one-step diagnosis of viremic HCV infection in human immunodeficiency virus (HIV)-coinfected individuals.

Methods

The study blindly tested HCV-Ags EIA for its performance in one-step diagnosing viremic HCV infection in 147 sera: 10 without HCV or HIV infection; 54 with viremic HCV monoinfection; 38 with viremic HCV/HIV coinfection; and 45 with viremic HCV and non-viremic HIV coinfection.

Results

Upon decoding, it was 100% accordance of HCV-Ags EIA to HCV infection status by HCV RNA PCR test. In five sera with HCV infection, HCV RNA was as low as 50-59 IU/mL, and four out of five tested positive for HCV-Ags EIA. Likewise, it was also 100% accordance of HCV-Ags EIA to HCV infection status by HCV RNA PCR in 83 sera with HCV and HIV coinfection, regardless if HIV infection was active or not.

Conclusion

The modified HCV-Ags EIA has a lower detection limit equivalent to serum HCV RNA levels of approximately 100 IU/mL. It is highly sensitive and specific in the setting of HIV coinfection, regardless of HIV infection status and CD4 count. These data support the clinical application of the HCV-Ags EIA in one-step diagnosis of HCV infection in HIV-infected individuals.