The immunodeficiency of human immunodeficiency virus type 1 (HIV-1) disease may be due to accelerated destruction of mature CD4+ T cells and/or impaired differentiation of progenitors of CD4+ T cells. HIV-1 infection may also inhibit the production of other hematopoietic lineages, by directly or indirectly suppressing the maturation of multilineage and/or lineage-restricted hematopoietic progenitor cells. To test this hypothesis, the effects of durable viral suppression on multilineage hematopoiesis in 66 HIV-1-seropositive patients were evaluated. Administration of effective antiretroviral therapy resulted in an increase in circulating CD4+ T cell counts and statistically significant increases in circulating levels of other hematopoietic lineages, including total white blood cells, lymphocytes, polymorphonuclear leukocytes, and platelets. These results suggest that a significant lesion in untreated HIV-1 disease may lie at the level of cell production from hematopoietic progenitors.

Purpose

To describe the theoretical rationale, intervention design, and clinical trial of a two-year weight control intervention for young adults deployed via social and mobile media.

Methods

A total of 404 overweight or obese college students from three Southern California universities (M(age) = 22( ± 4) years; M(BMI) = 29( ± 2.8); 70% female) were randomized to participate in the intervention or to receive an informational web-based weight loss program. The intervention is based on behavioral theory and integrates intervention elements across multiple touch points, including Facebook, text messaging, smartphone applications, blogs, and e-mail. Participants are encouraged to seek social support among their friends, self-monitor their weight weekly, post their health behaviors on Facebook, and e-mail their weight loss questions/concerns to a health coach. The intervention is adaptive because new theory-driven and iteratively tailored intervention elements are developed and released over the course of the two-year intervention in response to patterns of use and user feedback. Measures of body mass index, waist circumference, diet, physical activity, sedentary behavior, weight management practices, smoking, alcohol, sleep, body image, self-esteem, and depression occur at 6, 12, 18, and 24 months. Currently, all participants have been recruited, and all are in the final year of the trial.

Conclusion

Theory-driven, evidence-based strategies for physical activity, sedentary behavior, and dietary intake can be embedded in an intervention using social and mobile technologies to promote healthy weight-related behaviors in young adults.

We report a measurement of the branching fraction for ψ(3770)→γχc1 and search for the transition ψ(3770)→γχc2 based on 2.92 fb-1 of e+e- data accumulated at s=3.773 GeV with the BESIII detector at the BEPCII collider. We measure B(ψ(3770)→γχc1)=(2.48±0.15±0.23)×10-3, which is the most precise measurement to date. The upper limit on the branching fraction of ψ(3770)→γχc2 at a 90% confidence level is B(ψ(3770)→γχc2)<0.64×10-3. The corresponding partial widths are Γ(ψ(3770)→γχc1)=(67.5±4.1±6.7) keV and Γ(ψ(3770)→γχc2)<17.4 keV.

The process e+e−→ pp̄π0has been studied by analyzing data collected at (formula presented) GeV, at (formula presented) GeV, and during a ψ(3770) line shape scan with the BESIII detector at the BEPCII collider. The Born cross section of p̄pπ0in the vicinity of the ψ(3770) is measured, and the Born cross section of ψ(3770) → p̄pπ0is extracted considering interference between resonant and continuum production amplitudes. Two solutions with the same probability and a significance of 1.5 σ are found. The solutions for the Born cross section of ψ(3770) → p̄pπ0are 33.8 ± 1.8 ± 2.1 pb and (formula presented) pb (< 0.22 pb at a 90% confidence level). Using the estimated cross section and a constant decay amplitude approximation, the cross section σ(p̄p → ψ(3770)π0) is calculated for the kinematic situation of the planned P̄ANDA experiment. The maximum cross section corresponding to the two solutions is expected to be less than 0.79 nb at 90% confidence level and 122 ± 10 nb at a center-of-mass energy of 5.26 GeV.

From December 2011 to May 2014, about 5 fb-1 of data were taken with the BESIII detector at center-of-mass energies between 3.810 GeV and 4.600 GeV to study the charmonium-like states and higher excited charmonium states. The time-integrated luminosity of the collected data sample is measured to a precision of 1% by analyzing events produced by the large-angle Bhabha scattering process.

We study the decays of the charmonium resonances J/ψ and ψ(3686) to the final states Ξ-Ξ+, Σ(1385) Σ(1385)± based on a single baryon tag method using data samples of (223.7±1.4)×106 J/ψ and (106.4±0.9)×106 ψ(3686) events collected with the BESIII detector at the BEPCII collider. The decay ψ(3686)→Σ(1385) Σ(1385)± is observed for the first time, and the measurements of the other processes, including the branching fractions and angular distributions, are in good agreement with, and much more precise than, the previously published results. Additionally, the ratios B(ψ(3686)→Ξ-Ξ+)B(J/ψ→Ξ-Ξ+), B(ψ(3686)→Σ(1385)-Σ(1385)+)B(J/ψ→Σ(1385)-Σ(1385)+) and B(ψ(3686)→Σ(1385)+Σ(1385)-)B(J/ψ→Σ(1385)+Σ(1385)-) are determined.

We study D0D̅0 pairs produced in e+e− collisions at √ s = 3.773 GeVusing a data sample of 2.92 fb−1 collected with the BESIII detector. We measuredthe asymmetry ACPKπ of the branching fractions of D → K−π+ in CP-odd and CP-even eigenstates to be (12.7 ± 1.3 ± 0.7) × 10−2. ACPKπ can be used to extract the strong phase difference δKπ between the doubly Cabibbo-suppressed process D̅0 → K−π+ and the Cabibbo-favored process D0 → K−π+. Using world-average values of external parameters, we obtain cos δKπ = 1.02 ±0.11 ±0.06 ±0.01. Here, the first and second uncertainties are statistical and systematic, respectively, while the third uncertainty arises from the external parameters. This is the most precise measurement of δKπ to date.

Based on (106.41±0.86)×106 ψ(3686) events collected with the BESIII detector at the BEPCII collider, the branching fractions of ψ(3686)→π+π-J/ψ, J/ψ→e+e-, and J/ψ→μ+μ- are measured. We obtain B[ψ(3686)→π+π-J/ψ]=(34.98±0.02±0.45)%, B[J/ψ→e+e-]=(5.983±0.007±0.037)%, and B[J/ψ→μ+μ-]=(5.973±0.007±0.038)%. The measurement of B[ψ(3686)→π+π-J/ψ] confirms the CLEO-c measurement, and is apparently larger than the others. The measured J/ψ leptonic decay branching fractions agree with previous experiments within one standard deviation. These results lead to B[J/ψ→l+l-]=(5.978±0.005±0.040)% by averaging over the e+e- and μ+μ- channels and a ratio of B[J/ψ→e+e-]/B[J/ψ→μ+μ-]=1.0017±0.0017±0.0033, which tests e-μ universality at the four tenths of a percent level. All the measurements presented in this paper are the most precise in the world to date.

Using a sample of 1.3 × 10(9)  J/ψ events collected with the BESIII detector, we report the first observation of η(')→π(+)π(-)π(+)π(-) and η(')→π(+)π(-)π(0)π(0). The measured branching fractions are B(η(')→π(+)π(-)π(+)π(-)) = [8.53 ± 0.69(stat.) ± 0.64(syst.)]×10(-5) and B(η(')→π(+)π(-)π(0) π(0)) = [1.82 ± 0.35(stat.) ± 0.18(syst.)] × 10(-4), which are consistent with theoretical predictions based on a combination of chiral perturbation theory and vector-meson dominance.

Using 2.92 fb-1 of electron-positron annihilation data collected at √s = 3.773 GeV with the BESIII detector, we report the results of a search for the flavor-changing neutral current process D0 →γγ using a double-tag technique. We find no signal and set an upper limit at 90% confidence level for the branching fraction of B(D0 →γγ)< 3.8 × 10-6. We also investigate D0-meson decay into two neutral pions, obtaining a branching fraction of B(D0 →π0π0)= (8.24 ± 0.21(stat) ± 0.30(syst)) × 10-4, the most precise measurement to date and consistent with the current world average.