With the launching of the Precision Medicine Initiative in the United States, by the National Institute of Health, and the emergence of a large volume of electronic health records, there are many opportunities to improve clinical decision support systems. A large number of samples are needed to build predictive models that have adequate discrimination and calibration. However, protecting patient privacy is also an important issue. Patient data are typically protected in localized silos, and consolidation of datasets from different healthcare systems is difficult.

Federated learning allows the training of a global model by amassing intermediate calculations from localized medical systems. The knowledge learned from the data can be transferred and aggregated to achieve better performance than the one achieved by individual local models. Federated learning may help build better models, providing more accurate predictions. There are two types of measures to assess how well a model performs: discrimination and calibration. While most papers report discrimination measures, calibration has often been neglected but it is a critical metric for evaluation. In this dissertation, I show a novel way to build classifiers and calibration models in a federated manner. I also show how I can evaluate and improve model calibration in this manner. Federated modeling enables the accumulation of knowledge and information that are otherwise locked behind local medical systems.