University-based anthropology museums are uniquely positioned to pursue nuanced decisions concerning the disposition of collections in their care, setting best practice for the field. The authors describe a three-staged approach to repatriations that they led during their concurrent service as head of cultural policy and repatriation (Jordan Jacobs) and director (Benjamin Porter) of the University of California, Berkeley’s Phoebe A. Hearst Museum of Anthropology between 2015 and 2019. Examples involving human remains and cultural objects from Australia, Canada, Democratic Republic of the Congo, Iraq, Japan, Mexico, Panama, Peru, Saipan, Senegal, Vanuatu, Venezuela, and South Carolina in the United States demonstrate the benefits of transparency, open communication, and rigorous investigation of provenance and provenience, which may or may not lead to transfer based on the criteria and priorities of potential recipients. This article also provides a history of the Hearst Museum’s Cultural Policy and Repatriation division, which was disbanded in 2021.