We provide the unique affine crystal structure for type E_6^{(1)}
Kirillov-Reshetikhin crystals corresponding to the multiples of fundamental weights s
Lambda_1, s Lambda_2, and s Lambda_6 for all s \geq 1 (in Bourbaki's labeling of the Dynkin
nodes, where 2 is the adjoint node). Our methods introduce a generalized tableaux model for
classical highest weight crystals of type E and use the order three automorphism of the
affine E_6^{(1)} Dynkin diagram. In addition, we provide a conjecture for the affine
crystal structure of type E_7^{(1)} Kirillov-Reshetikhin crystals corresponding to the
adjoint node.