California pistachio growers have long relied on a single female (‘Kerman’) and single male (‘Peters’) cultivar. Despite their benefits, these cultivars present important production and marketing concerns. To evaluate new varieties for the pistachio industry, we conducted the first randomized and replicated pistachio variety trials in the San Joaquin Valley, where most U.S. pistachios are grown. After more than a decade of scientific evaluation, several varieties new to California (such as ‘Kalehghouchi’) or the world (such as ‘Golden Hills’) demonstrated commercial potential for the California pistachio industry and would complement the production characteristics of ‘Kerman’.