• We suspect that our first patient’s presentation with discolored and foul-smelling urine may reflect amebic spread to the urinary tract • Our case of B. mandrillaris had the expected CSF abnormalities for amebic encephalitis • Lymphocytic pleocytosis • Elevated protein (peaked at 913 mg/dl) • Persistent hypoglycorrhachia • Our case of N. fowleri did not have characteristic CSF findings • Glucose remained normal • Typically, N. fowleri presents with a lower CSF glucose than B. mandrillaris – our cases show the opposite findings