This response addresses aspects of biopolitical regulations by Canada, El Salvador, Australia, and the United States, as critically analyzed in the special issue. Each piece offers much to illuminate different modalities of regulating Indigenous lifeways and Indigenous peoples' resistance to them on myriad grounds, and this response engages three particular themes that emerge from these articles: (1) structural genocide in settler-colonial states' attempts at deracination; (2) Indigenous peoples' agency with regard to anti-normalization; and (3) decolonial resistance outside of imposed settler-colonial binaries. All three aspects challenge the “logic of elimination of the Native” that, as theorized by Patrick Wolfe, is endemic to settler colonialism. The piece also offers some thoughts on these same three key nodes in the case of Hawai‘i and the United States.