Thinking aloud protocols previously obtained by Joseph and Patcl were re-analyzed to determine the extent to which their conclusions could be replicated by independently developed coding schemes. The data set consisted of protocols from 4 cardiologists (low domain knowledge = LDK) and 4 endocrinologists (high domain knowledge = H D K ) , individually woricing on a diagnostic problem in endocrinology. Both analyses found that H D K physicians related daU to potential diagnoses more than the L D K group, and that there were trends for H D K physicians to be more focused on the correct diagnostic components and to employ more single-cue inference and less multiple-cue inference. However, the re-analysis found no meaningful differences between groups in diagnostic accuracy, speed of diagnosis, or in the breadth of the search space used to seek a solution. The generalizability of results of protocol-analysis studies can be assessed by using several complementary coding schemes.