- Matthay, Michael;
- Pittet, JF;
- Koh, H;
- Fang, X;
- Iles, K;
- Christiaans, S;
- Anjun, N;
- Wagener, BM;
- Park, DW;
- Zmijewski, JW;
- Matthay, MA
High mobility group box 1 (HMGB1) protein is a danger-signaling molecule, known to activate an inflammatory response via TLR4 and RAGE. HMGB1 can be either actively secreted or passively released from damaged alveolar epithelial cells. Previous studies hav