Skip to main content
eScholarship
Open Access Publications from the University of California

Scholarly Works (1 results)

  • Article
  • Peer Reviewed
UC San Francisco Previously Published Works (2013)
Template-constrained cyclic sulfopeptides that inhibit HIV-1 entry were rationally designed based on a loop from monoclonal antibody (mAb) 412d. A focused set of sulfopeptides was synthesized using Fmoc-Tyr(SO3DCV)-OH (DCV = 2,2-dichlorovinyl). Three cyclic sulfopeptides that inhibit entry of HIV-1 and complement the activity of known CCR5 antagonists were identified.
    Cover page: Template-constrained cyclic sulfopeptide HIV-1 entry inhibitors
    Top