Over the last several decades, much research has been carried out to determine the cause, progression and prevalence of Age-Related Macular Degeneration which is currently known to be the leading cause of blindness in elderly Americans. By in large, studies have yielded insignificant results. This paper reviews three key areas of research including associations between 1) macular pigment density, 2) omega-3 polyunsaturated fatty acid, 3) antioxidant vitamins (including vitamins C, E and beta-carotene) and the incidence of Age-Related Macular Degeneration. The ensuing discussion attempts to convey to the reader that much of what is understood by the general public about nutritional supplementation and Age-Related Macular Degeneration is at best inconclusive and potentially hazardous.