HCl in solution accepts electron density from Au NPs and partially reduces at room temperature, as occurs with other simple diatomic molecules, such as O₂ and H₂ . The activation can be run catalytically in the presence of alkynes to give exclusively E-vinyl chlorides, after the regio- and stereoselective transfer of HCl. Based also on this method, vinyl chloride monomer (VCM) can be produced in a milder and greener way than current industrial processes.

The synthesis of ligand-free sub-nanometric metal clusters on a large scale suffers typically from very low yields (<5% yield) and needs very high dilutions. Here we show that Au clusters can be prepared with ethylene-vinyl alcohol copolymers (EVOH), charcoal, and different metal oxides (CeO₂, Al₂O₃, TiO₂ and ZnO) in >15% yields, as unambiguously determined using a very simple and extremely sensitive analytical reaction test.