This report summarizes the layout and content of a website created for the CEC to make the information in the Energy Aware Planning Guide readily available to California cities and counties, to assist them in their efforts to reduce energy use. The website consists of an electronic version of the entire Planning Guide that allows easy maneuverability among the many sections of the document, and quick downloading of references cited in the document. The website also contains individual briefing pages for 46 land use- and transportation-related measures, including 21 briefs that provide information on additional transportation-related measures that are not specifically identified in the Planning Guide. The website also summarizes estimates of the effectiveness of individual measures described in the briefings, as well as the cost-effectiveness of each measure, derived from a comprehensive national study of the potential to reduce energy use from the transportation sector

Several genetic risk factors for Alzheimers disease implicate genes involved in lipid metabolism and many of these lipid genes are highly expressed in glial cells1. However, the relationship between lipid metabolism in glia and Alzheimers disease pathology remains poorly understood. Through single-nucleus RNA sequencing of brain tissue in Alzheimers disease, we have identified a microglial state defined by the expression of the lipid droplet-associated enzyme ACSL1 with ACSL1-positive microglia being most abundant in patients with Alzheimers disease having the APOE4/4 genotype. In human induced pluripotent stem cell-derived microglia, fibrillar Aβ induces ACSL1 expression, triglyceride synthesis and lipid droplet accumulation in an APOE-dependent manner. Additionally, conditioned media from lipid droplet-containing microglia lead to Tau phosphorylation and neurotoxicity in an APOE-dependent manner. Our findings suggest a link between genetic risk factors for Alzheimers disease with microglial lipid droplet accumulation and neurotoxic microglia-derived factors, potentially providing therapeutic strategies for Alzheimers disease.