An online cross-sectional survey was used to examine 475 adults (239 men and 236 women) on physical activity level, barriers to physical activity participation, and attitudes towards personal aging. Participants were grouped, by citizenship and residence, as Indians in India, Indians in the United States, or Americans in the United States. Cross-cultural differences were observed on self-rated general health, occurrence of preventive examinations, and several barriers to physical activity. Physical activity level was positively correlated with self-rated general health, and with optimism regarding aging, suggesting that enhanced physical activity may hold the key to a higher evaluation of personal health, and more positive expectations of aging.