The United Nations Security Council (UNSC) is entrusted with the responsibility of safeguarding global peace and security. Prominent global security concerns will be deliberated upon, and viewpoints will be presented within the UNSC. Analyzing the cognitive patterns from UNSC debates helps scholars gain insights into the intricacies of international relations and diplomatic discourse. In this study, our focus lies in the cognitive analysis of debates held within the UNSC. We employ metaphors and their associated concept mappings as a methodological tool to dissect the cognitive nuances present in the debates, spanning from January 1995 to December 2020. To undertake this extensive analysis from a large volume of documents, we leverage MetaPro, a state-of-the-art computational metaphor processing system to obtain the concept mappings of metaphors. We analyze cognitive variations by temporal and geographical variables. We also demonstrate the correlation between metaphor-reflected cognition and diplomatic behavior, and their recursive influence, based on large sample research. Our major finding highlights the mutual impacts of metaphorical cognition and voting behavior at the UN.

Many patients with hepatocellular carcinoma (HCC) do not respond to the first-line immune checkpoint inhibitor treatment. Immunization with effective cancer vaccines is an attractive alternative approach to immunotherapy. However, its efficacy remains insufficiently evaluated in preclinical studies. Here, we investigated HCC-associated self/tumor antigen, α-fetoprotein-based (AFP-based) vaccine immunization for treating AFP (+) HCC mouse models. We found that AFP immunization effectively induced AFP-specific CD8+ T cells in vivo. However, these CD8+ T cells expressed exhaustion markers, including PD1, LAG3, and Tim3. Furthermore, the AFP vaccine effectively prevented c-MYC/Mcl1 HCC initiation when administered before tumor formation, while it was ineffective against full-blown c-MYC/Mcl1 tumors. Similarly, anti-PD1 and anti-PD-L1 monotherapy showed no efficacy in this murine HCC model. In striking contrast, AFP immunization combined with anti-PD-L1 treatment triggered significant inhibition of HCC progression in most liver tumor nodules, while in combination with anti-PD1, it induced slower tumor progression. Mechanistically, we demonstrated that HCC-intrinsic PD-L1 expression was the primary target of anti-PD-L1 in this combination therapy. Notably, the combination therapy had a similar therapeutic effect in the cMet/β-catenin mouse HCC model. These findings suggest that combining the AFP vaccine and immune checkpoint inhibitors may be effective for AFP (+) HCC treatment.