Muskmelons (Cucumis melo L.) are a key agricultural commodity in the southwestern U.S., with California and Arizona producing the majority of U.S. cantaloupe and honeydew. However, production has been severely impacted since the 1980s due to insect vectors, including the silverleaf whitefly (Bemisia tabaci MEAM1) and aphid species, such as the cotton-melon aphid (Aphis gossypii) and green peach aphid (Myzus persicae). Not only do they cause direct damage at high populations, but they also serve as vectors for viruses, such as cucurbit yellowing stunting disorder virus (CYSDV) and zucchini yellow mosaic virus (ZYMV), leading to substantial crop losses. New viruses emerge every 3-4 years, complicating management strategies across different growing regions, including the central San Joaquin Valley and the low desert valleys of California. Current management predominantly relies on insecticides, which can be insufficient to prevent rapidly transmitted viruses and can lead to issues such as resistance and can cause negative impacts on environmental and human health. This ongoing issue underscores the need for alternative management strategies aimed at mitigating virus infections during the initial stages of infection. As an alternative strategy, this study investigates the use of plant defense activators, or elicitors, which induce plant immunity responses to protect against incoming pathogen infection by suppressing disease symptoms and replication, which ultimately protects against yield losses. This study aims to evaluate underexplored elicitor options for prolonging and improving this induced resistance against primary melon viruses. This study also aims to assess the efficacy of elicitors in melon crops grown under field conditions that closely mimic commercial production practices. Here, we evaluate elicitors in conjunction with an insecticide regime to determine the feasibility of reducing overall pesticide use or employing more pollinator-safe pesticides while effectively managing virus pressure. These findings contribute to the broader understanding of elicitor efficacy for virus control and reinforce the importance of exploring understudied elicitors, or other alternative approaches for disease management. This integrated approach aims to advance sustainable pest management practices in melon production while mitigating the impact of insect-transmitted viruses.