Purpose. To report the use of femtosecond laser-assisted in situ keratomileusis (LASIK) in the treatment of hyperopia subsequent to Descemet stripping-automated endothelial keratoplasty (DSAEK). Methods. Interventional case report. Results. A 66-year-old woman with Fuchs endothelial dystrophy developed bullous keratopathy after cataract surgery in her right eye. She underwent DSAEK with a significant postoperative hyperopic shift in her refraction. Thirteen months after DSAEK, she underwent wavefront-guided, femtosecond laser-assisted LASIK (IntraLase, Inc., Irvine, CA/AMO, Inc., IL, USA). Pretreatment unaided visual acuity was 20/120, and best-corrected visual acuity was 20/20 with a refraction of +3.25/-0.50 × 170. One year after laser refractive correction, unaided visual acuity was 20/20 with a refraction of +0.25/-0.75 × 160. Conclusion. To our knowledge, this is the first paper on the successful treatment of hyperopic shift related to DSAEK with wavefront-guided, femtosecond laser-assisted LASIK.