NH radicals from a molecular beam are cooled using a novel beam-loaded buffer gas method. The radicals are produced in a glow discharge beam source and injected into cryogenic helium gas. Up to 1012 molecules in their ground electronic, vibrational, and rotational state are detected in the buffer gas and translational temperatures under 6 K are achieved. The cooling method presented is general and can be applied to any molecules in a molecular beam. © EDP Sciences, Società Italiana di Fisica, Springer-Verlag 2004.