Adherence interventions were implemented in a 1-year community-based colon cancer prevention clinical trial (n = 110) using wheat bran fiber and calcium dietary supplements. The adherence promotion strategy was guided by a theoretical model.

The adherence intervention contains both a generalized portion given to all participants and an individualized portion given to marginal (50-74% intake) and low (under 50% intake) adherers. A regression model was employed to assess the effectiveness of the interventions both at the first intervention and at subsequent times.

The Health Behavior in Cancer Prevention Model-based adherence promotion intervention was associated with retention of participants, both during the run-in period and after randomization (P = 0.05); and maximization of the percentage of the 13.5-g recommended fiber supplement consumed during the trial (92.5%). The positive effects of the adherence intervention were greater with first-time nonadherers and the control group than with the experimental group. The high-fiber group had notably more biological GI effects from the increased fiber intake, more preexisting comorbidities, and lower perceived cognitive and physical health status.

Randomized participants had excellent adherence overall. Retention rates in the trial were better than would be expected without the adherence intervention, especially among those participants who may have been at higher risk for dropping out of the study. This suggests that a systematic, theoretically based adherence strategy should be further tested in clinical trial settings in which lower adherence is a problem.

This study identified participants' reasons for good, marginal or poor adherence, or withdrawing from community-based clinical studies using a dietary and/or drug intervention. Adults aged 48-75 years participated in one of three studies related to decreasing colon polyp recurrence. Qualitative data from progress notes (N = 675) and end-of-study evaluations (N = 87) were coded using constant comparative analysis with 100% content validity panel agreement. Most common reasons for non-adherence were barriers such as side-effects, interference with vacation plans, unrelated illness, forgetting and competing outside stressors. Participation motivators were benefits such as altruism, medical benefits, free service and staff rapport. Findings supported the Health Behavior in Cancer Prevention model-based approach to adherence interventions and provided directions for adherence promotion in future community-based clinical studies.

An array of Neutral-Current Detectors (NCDs) has been built in order to make a unique measurement of the total active ux of solar neutrinos in the Sudbury Neutrino Observatory (SNO). Data in the third phase of the SNO experiment were collected between November 2004 and November 2006, after the NCD array was added to improve the neutral-current sensitivity of the SNO detector. This array consisted of 36 strings of proportional counters lled with a mixture of 3He and CF4 gas capable of detecting the neutrons liberated by the neutrino-deuteron neutral current reaction in the D2O, and four strings lled with a mixture of 4He and CF4 gas for background measurements. The proportional counter diameter is 5 cm. The total deployed array length was 398 m. The SNO NCD array is the lowest-radioactivity large array of proportional counters ever produced. This article describes the design, construction, deployment, and characterization of the NCD array, discusses the electronics and data acquisition system, and considers event signatures and backgrounds.

A search has been made for neutrinos from the hep reaction in the Sun and from the diffuse supernova neutrino background (DSNB) using data collected during the first operational phase of the Sudbury Neutrino Observatory, with an exposure of 0.65 kilotonne-years. For the hep neutrino search, two events are observed in the effective electron energy range of 14.3 MeV < Teff < 20 MeV where 3.1 background events are expected. After accounting for neutrino oscillations, an upper limit of 2.3 x 104 cm-2s-1 at the 90 percent confidence level is inferred on the integral total flux of hep neutrinos. For DSNB neutrinos, no events are observed in the effective electron energy range of 21 MeV < Teff < 35 MeV and, consequently, an upper limit on the nu e component of the DSNB fluxin the neutrino energy range of 22.9 MeV < E nu < 36.9 MeV of 70 cm-2-1 is inferred at the 90 percent confidence level. This is an improvement by a factor of 6.5 on the previous best upper limit on the hep neutrino flux and by two orders of magnitude on the previous upper limit on the nu e component of the DSNB flux.

Results are reported from the complete salt phase of the Sudbury Neutrino Observatory experiment in which NaCl was dissolved in the D_2O target. The addition of salt enhanced the signal from neutron capture, as compared to the pure D_2O detector. By making a statistical separation of charged-current events from other types based on event-isotropy criteria, the effective electron recoil energy spectrum has been extracted. In units of 106 cm-2 s-1, the total flux of active-flavor neutrinos from 8B decay in the Sun is found to be 4.94+0.21_-0.21(stat)+0.38_-0.34(syst) and the integral flux of electron neutrinos for an undistorted 8B spectrum is 1.68+0.06_-0.06(stat)+0.08_-0.09(syst); the signal from (nu_x,e) elastic scattering is equivalent to an electron-neutrino flux of 2.35+0.22-0.22(stat)+0.15_-0.15(syst). These results are consistent with those expected for neutrino oscillations with the so-called Large Mixing Angle parameters, and also with an undistorted spectrum. A search for matter-enhancement effects in the Earth through a possible day-night asymmetry in the charged-current integral rate is consistent with no asymmetry. Including results from other experiments, the best-fit values for two-neutrino mixing parameters are Delta m2 = (8.0+0.6_-0.4) x 10-5 eV2 and theta = 33.9 +2.4_-2.2 degrees.

This article provides the complete description of results from the Phase I data set of the Sudbury Neutrino Observatory (SNO). The Phase I data set is based on a 0.65 kt-year exposure of heavy water to the solar 8B neutrino flux. Included here are details of the SNO physics and detector model, evaluations of systematic uncertainties, and estimates of backgrounds. Also discussed are SNO's approach to statistical extraction of the signals from the three neutrino reactions (charged current, neutral current, and elastic scattering) and the results of a search for a day-night asymmetry in the ?e flux. Under the assumption that the 8B spectrum is undistorted, the measurements from this phase yield a solar ?e flux of ?(?e) = 1.76+0.05?0.05(stat.)+0.09?0.09 (syst.) x 106 cm?2 s?1, and a non-?e component ?(? mu) = 3.41+0.45?0.45(stat.)+0.48?0.45 (syst.) x 106 cm?2 s?1. The sum of these components provides a total flux in excellent agreement with the predictions of Standard Solar Models. The day-night asymmetry in the ?e flux is found to be Ae = 7.0 +- 4.9 (stat.)+1.3?1.2 percent (sys.), when the asymmetry in the total flux is constrained to be zero.