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Open Access Publications from the University of California

Scholarly Works (25 results)

  • Article
  • Peer Reviewed
UC San Diego Previously Published Works (2020)
    Creative Commons 'BY-NC-ND' version 4.0 license
    • Article
    LBL Publications (2002)

    Price-responsive load (PRL) programs vary significantly in overall design, the complexity of relationships between program administrators, load aggregators, and customers, and the availability of "enabling technologies". Enabling technologies include such features as web-based power system and price monitoring, control and dispatch of curtailable loads, communications and information systems links to program participants, availability of interval metering data to customers in near real time, and building/facility/end-use automation and management capabilities. Two state agencies - NYSERDA in New York and the CEC in California - have been conspicuous leaders in the demonstration of demand response (DR) programs utilizing enabling technologies. In partnership with key stakeholders in these two states (e.g., grid operator, state energy agencies, and program administrators), Lawrence Berkeley National Laboratory (LBNL) and Pacific Northwest National Laboratory (PNNL) surveyed 56 customers who worked with five contractors participating in CEC or NYSERDA-sponsored DR programs. We combined market research and actual load curtailment data when available (i.e., New York) or customer load reduction targets in order to explore the relative importance of contractor's program design features, sophistication of control strategies, and reliance on enabling technologies in predicting customer's ability to deliver load reductions in DR programs targeted to large commercial/industrial customers. We found preliminary evidence that DR enabling technology has a positive effect on load curtailment potential. Many customers indicated that web-based energy information tools were useful for facilitating demand response (e.g., assessing actual performance compared to load reduction contract commitments), that multiple notification channels facilitated timely response, and that support for and use of backup generation allowed customers to achieve significant and ! predictable load curtailments. We also found that 60-70 percent of the customers relied on manual approaches to implementing load reductions/curtailments, rather than automated load control response. The long-term sustainability of customer load curtailments would be significantly enhanced by automated load response capabilities, such as optimizing EMCS systems to respond to day-ahead energy market prices or load curtailments in response to system emergencies.

      Cover page: Do "enabling technologies" affect customer performance in price-responsive load programs?
      • Article
      LBL Publications (2002)
        Cover page: Impact of enabling technologies on customer load curtailment performance: Summer 2001 results from NYSERDA's PON 585 and 577 programs and NYISO's emergency demand response program
        • Article
        • Peer Reviewed
        UC San Diego Previously Published Works (2020)
          • Article
          • Peer Reviewed
          UC San Diego Previously Published Works (2023)
          The Future of Design Education working group on product-service systems addressed growing college-level interest in the design of product-service systems. It recognized that the existence and maturity of service design programs varies widely, as do faculty expertise and the disciplinary affiliations of programs within institutions, all of which present opportunities to expand the scale and scope of its teaching. The working group defined designers’ core contributions to the interdisciplinary practice as human-centered, systems-oriented approaches. It also acknowledged that organizational knowledge—in governance and policy, infrastructure, strategy, and operational processes—is integral to designing effective products, services, and experiences, as well as the policies, processes, and mechanisms that deliver them. Likewise, an understanding of technology and data is critical to the design of contemporary product-service systems. Framing product-service relationships as ecologies, the working group described services as being more than one-time consumer transactions with effects in larger environmental, social, and technical systems. The group clustered its curricular recommendations under three themes: 1) defining the contours of the field, 2) designing for living systems that evolve with a changing environment and opportunities, and 3) building visions of the future.
            Creative Commons 'BY-NC-ND' version 4.0 license
            • Article
            • Peer Reviewed
            UC Davis Previously Published Works (2010)
            Environmental releases of antibiotics from concentrated animal feeding operations (CAFOs) are of increasing regulatory concern. This study investigates the use and occurrence of antibiotics in dairy CAFOs and their potential transport into first-encountered groundwater. On two dairies we conducted four seasonal sampling campaigns, each across 13 animal production and waste management systems and associated environmental pathways: application to animals, excretion to surfaces, manure collection systems, soils, and shallow groundwater. Concentrations of antibiotics were determined using on line solid phase extraction (OLSPE) and liquid chromatography-tandem mass spectrometry (LC/MS/MS) with electrospray ionization (ESI) for water samples, and accelerated solvent extraction (ASE) LC/MS/MS with ESI for solid samples. A variety of antibiotics were applied at both farms leading to antibiotics excretion of several hundred grams per farm per day. Sulfonamides, tetracyclines, and their epimers/isomers, and lincomycin were most frequently detected. Yet, despite decades of use, antibiotic occurrence appeared constrained to within farm boundaries. The most frequent antibiotic detections were associated with lagoons, hospital pens, and calf hutches. When detected below ground, tetracyclines were mainly found in soils, whereas sulfonamides were found in shallow groundwater reflecting key differences in their physicochemical properties. In manure lagoons, 10 compounds were detected including tetracyclines and trimethoprim. Of these 10, sulfadimethoxine, sulfamethazine, and lincomycin were found in shallow groundwater directly downgradient from the lagoons. Antibiotics were sporadically detected in field surface samples on fields with manure applications, but not in underlying sandy soils. Sulfadimethoxine and sulfamethazine were detected in shallow groundwater near field flood irrigation gates, but at highly attenuated levels.
              Cover page: Use and Environmental Occurrence of Antibiotics in Freestall Dairy Farms with Manured Forage Fields
              • Article
              • Peer Reviewed
              Research Grants Program Office (RGPO) Funded Publications (2018)
              Treatment of drug addiction remains an unmet medical need due to the dearth of approved pharmacotherapies. There are no approved treatments for cocaine addiction, whereas the current opioid crisis has revealed the stark reality of the limited options to treat prescription and illicit opioid abuse. Preclinical studies in rodents and nonhuman primates have shown that orphanin FQ/nociceptin (N/OFQ), the endogenous ligand for the nociceptin opioid receptor (NOP) reduces the rewarding effects of several abused substances, including opioids, psychostimulants and alcohol. A few nonpeptide small-molecule NOP agonists have also shown efficacy in attenuating the rewarding effects of various abused drugs. We previously demonstrated that a high affinity small-molecule NOP agonist AT-312 selectively reduced the rewarding effects of ethanol in the conditioned place preference paradigm in mice. In the present study, we examined if AT-312 (3 mg/kg, i.p. or s.c. respectively), would alter the rewarding action of morphine (7.5 mg/kg, s.c.) or cocaine (15 mg/kg, i.p.). The effect of AT-312 on morphine- and cocaine-induced motor stimulation was also assessed on the conditioning days. The role of the NOP receptor in the effects of AT-312 was further confirmed by conducting the place conditioning experiments in NOP knockout mice and compared to their wild-type controls. Our results showed that AT-312 significantly reduced the acquisition of morphine and cocaine CPP in wild-type mice but not in mice lacking NOP receptors. AT-312 also suppressed morphine-induced and completely abolished cocaine-induced motor stimulation in NOP wild-type mice, but not in NOP knockout mice. These results show that small-molecule NOP receptor agonists have promising efficacy for attenuating the rewarding effects of morphine and cocaine, and may have potential as pharmacotherapy for opioid and psychostimulant addiction or for treating polydrug addiction.
                Cover page: The Nociceptin Receptor (NOP) Agonist AT-312 Blocks Acquisition of Morphine- and Cocaine-Induced Conditioned Place Preference in Mice
                • Article
                • Peer Reviewed
                Research Grants Program Office (RGPO) Funded Publications (2018)

                Background

                Nociceptin/orphanin FQ, the endogenous peptide agonist for the opioid receptor-like receptor (also known as NOP or the nociceptin receptor), has been shown to block the acquisition and expression of ethanol (EtOH)-induced conditioned place preference (CPP). Here, we report the characterization of a novel small-molecule NOP ligand AT-312 (1-(1-((cis)-4-isopropylcyclohexyl)piperidin-4-yl)-1H-indol-2-yl)methanol) in receptor binding and GTPγS functional assays in vitro. We then investigated the effect of AT-312 on the rewarding action of EtOH in mice using the CPP paradigm. Further, using mice lacking the NOP receptor and their wild-type controls, we also examined the involvement of NOP in the effect of AT-312. Motivational effects of AT-312 alone were also assessed in the CPP paradigm.

                Methods

                Female mice lacking NOP and/or their wild-type controls received conditioning in the presence or absence of the NOP agonist [AT-312 (1, 3, and 10 mg/kg) or the control NOP agonist SCH221510 (10 mg/kg)] followed by saline/EtOH for 3 consecutive days (twice daily) and tested for CPP in a drug-free state on the next day.

                Results

                Our in vitro data showed that AT-312 is a high-affinity, selective NOP full agonist with 17-fold selectivity over the mu opioid receptor and >200-fold selectivity over the kappa opioid receptor. The results of our in vivo studies showed that AT-312 reduced EtOH CPP at the lowest dose (1 mg/kg) tested but completely abolished EtOH CPP at higher doses (3 or 10 mg/kg) compared to their vehicle-treated control group. AT-312 (3 mg/kg) did not alter EtOH-induced CPP in mice lacking NOP, confirming that AT-312 reduced EtOH CPP through its action at the NOP receptor. AT-312 (3 mg/kg) did not induce reward or aversion when administered alone, showing that the novel small-molecule NOP agonist shows efficacy in blocking EtOH-induced CPP via the NOP receptor.

                Conclusions

                Together, these data suggest that small-molecule NOP agonists have the potential to reduce alcohol reward and may be promising as medications to treat alcohol addiction.
                  Cover page: A Novel and Selective Nociceptin Receptor (NOP) Agonist (1‐(1‐((cis)‐4‐isopropylcyclohexyl)piperidin‐4‐yl)‐1H‐indol‐2‐yl)methanol (AT‐312) Decreases Acquisition of Ethanol‐Induced Conditioned Place Preference in Mice
                  • Article
                  • Peer Reviewed
                  UC San Francisco Previously Published Works (2020)
                  An increasing population in conjunction with a changing climate necessitates a detailed understanding of water abundance at multiple spatial and temporal scales. Remote sensing has provided massive data volumes to track fluctuations in water quantity, yet contextualizing water abundance with other local, regional, and global trends remains challenging by often requiring large computational resources to combine multiple data sources into analytically-friendly formats. To bridge this gap and facilitate future freshwater research opportunities, we harmonized existing global datasets to create the Global Lake area, Climate, and Population (GLCP) dataset. The GLCP is a compilation of lake surface area for 1.42 + million lakes and reservoirs of at least 10 ha in size from 1995 to 2015 with co-located basin-level temperature, precipitation, and population data. The GLCP was created with FAIR (findable, accessible, interoperable, reusable) data principles in mind and retains unique identifiers from parent datasets to expedite interoperability. The GLCP offers critical data for basic and applied investigations of lake surface area and water quantity at local, regional, and global scales.
                    Creative Commons 'BY' version 4.0 license
                    • Article
                    • Peer Reviewed
                    UC Santa Cruz Previously Published Works (2016)
                    Spectral retrieval has proven to be a powerful tool for constraining the physical properties and atmospheric compositions of extrasolar planet atmospheres from observed spectra, primarily for transiting objects but also for directly imaged planets and brown dwarfs. Despite its strengths, this approach has been applied to only about a dozen targets. Determining the abundances of the main carbon and oxygen-bearing compounds in a planetary atmosphere can lead to the C/O ratio of the object, which is crucial in understanding its formation and migration history. We present a retrieval analysis on the published near-infrared spectrum of {\kappa} And b, a directly imaged substellar companion to a young B9 star. We fit the emission spectrum model utilizing a Markov Chain Monte Carlo algorithm. We estimate the abundance of water vapor, and its uncertainty, in the atmosphere of the object. In addition, we place an upper limit on the abundance of CH$_4$. We compare qualitatively our results to studies that have applied model retrieval on multiband photometry and emission spectroscopy of hot Jupiters (extrasolar giant planets with orbital periods of several days) and the directly imaged giant planet HR 8799b.
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