This paper introduces a novel technique for access by a cognitive Secondary User (SU) using best-effort transmission to a spectrum with an incumbent Primary User (PU), which uses Type-I Hybrid ARQ. The technique leverages the primary ARQ protocol to perform Interference Cancellation (IC) at the SU receiver (SUrx). Two IC mechanisms that work in concert are introduced: Forward IC, where SUrx, after decoding the PU message, cancels its interference in the (possible) following PU retransmissions of the same message, to improve the SU throughput; Backward IC, where SUrx performs IC on previous SU transmissions, whose decoding failed due to severe PU interference. Secondary access policies are designed that determine the secondary access probability in each state of the network so as to maximize the average long-term SU throughput by opportunistically leveraging IC, while causing bounded average long-term PU throughput degradation and SU power expenditure. It is proved that the optimal policy prescribes that the SU prioritizes its access in the states where SUrx knows the PU message, thus enabling IC. An algorithm is provided to optimally allocate additional secondary access opportunities in the states where the PU message is unknown. Numerical results are shown to assess the throughput gain provided by the proposed techniques. © 1983-2012 IEEE.