Vibrio cholerae is an environmental pathogen that relies on biofilm formation for its infectivity.Here we investigate a genomic region that we suspect is involved in regulation of V. cholerae
biofilm formation in response to environmental signals. The genomic region is particularly
enriched in two component system proteins with domains that are able to degrade c-di-GMP.
The genomic region spans from VC1080 to VC1087 in the V. cholerae genome and will be
referred to as the VC1080 operon. This study provides information on the VC1080 to VC1087
gene products obtained by various bioinformatic analysis and presents results from the initial
studies investigating the influence of each gene on V. cholerae biofilm formation and motility.