Urban air temperature rises induced by the urban heat island (UHIE) effect or by global warming (GW) can be beneficial in winter but detrimental in summer. The SCIENCE-Outdoor model was used to simulate changes to sensible heat release and CO2 emissions from buildings yielded by four UHIE countermeasures and five GW countermeasures. This model can evaluate the thermal condition of building envelope surfaces, both inside and outside. The results showed that water-consuming UHIE countermeasures such as evaporative space cooling and roof water showering provided positive effects (decreasing sensible heat release and CO2 emissions related to space conditioning) in summer. Additionally, they had no negative (unwanted cooling) effects in winter since they can be turned off in the heating season. Roof greening can provide the greatest space-conditioning CO2 emissions reductions among four UHIE countermeasures, and it reduces the amount of heat release slightly in the heating season. Since the effect on reducing carbon dioxide (CO2) emissions by UHIE countermeasures is not very significant, it is desirable to introduce GW countermeasures in order to reduce CO2 emissions. The significance of this study is that it constructed the new simulation model SCIENCE-Outdoor and applied it to show the influence of countermeasures upon both heat release and CO2 emissions.