- Meagher, Margaret;
- Krause, Harris;
- Elliott, Andrew;
- Farrell, Alex;
- Antonarakis, Emmanuel;
- Bastos, Bruno;
- Heath, Elisabeth;
- Jamieson, Christina;
- Stewart, Tyler;
- Bagrodia, Aditya;
- Nabhan, Chadi;
- Oberley, Matt;
- McKay, Rana;
- Salmasi, Amirali
BACKGROUND: Non-canonical WNT family (WNT5A pathway) signaling via WNT5A through ROR1 and its partner, ROR2, or Frizzled2 (FZD2) is linked to processes driving tumorigenesis and therapy resistance. We utilized a large dataset of urothelial carcinoma (UC) tumors to characterize non-canonical WNT signaling through WNT5A, ROR1, ROR2, or FZD2 expression. METHODS: NextGen Sequencing of DNA (592 genes or WES)/RNA (WTS) was performed for 4125 UC tumors submitted to Caris Life Sciences. High and low expression of WNT5A, ROR1, ROR2, and FZD2 was defined as ≥ top and