The axoneme-the conserved core of eukaryotic cilia and flagella-contains highly specialized doublet microtubules (DMTs). A long-standing question is what protein(s) compose the junctions between two tubules in DMT. Here we identify a highly conserved flage

This synthesis discusses the emissions of carbon dioxide from fossil-fuel combustion and cement production. While much is known about these emissions, there is still much that is unknown about the details surrounding these emissions. This synthesis explores our knowledge of these emissions in terms of why there is concern about them; how they are calculated; the major global efforts on inventorying them; their global, regional, and national totals at different spatial and temporal scales; how they are distributed on global grids (i.e., maps); how they are transported in models; and the uncertainties associated with these different aspects of the emissions. The magnitude of emissions from the combustion of fossil fuels has been almost continuously increasing with time since fossil fuels were first used by humans. Despite events in some nations specifically designed to reduce emissions, or which have had emissions reduction as a byproduct of other events, global total emissions continue their general increase with time. Global total fossil-fuel carbon dioxide emissions are known to within 10 % uncertainty (95 % confidence interval). Uncertainty on individual national total fossil-fuel carbon dioxide emissions range from a few percent to more than 50 %. This manuscript concludes that carbon dioxide emissions from fossil-fuel combustion continue to increase with time and that while much is known about the overall characteristics of these emissions, much is still to be learned about the detailed characteristics of these emissions.

We report a measurement of the Type Ia supernova (SN Ia) rate in galaxy clusters at 0.9 < z < 1.46 from the Hubble Space Telescope Cluster Supernova Survey. This is the first cluster SN Ia rate measurement with detected z > 0.9 SNe. Finding 8 1 cluster SNeIa, we determine an SN Ia rate of 0.50+0.23-0.19 (stat) +0.10-0.09 (sys) h 270 SNuB (SNuB ≡ 10-12 SNe L -1, Byr-1). In units of stellar mass, this translates to 0.36+0.16-0.13 (stat) +0.07-0.06 (sys) h 270 SNuM (SNuM ≡ 10 -12 SNe M -1⊙yr-1). This represents a factor of 5 2 increase over measurements of the cluster rate at z < 0.2. We parameterize the late-time SN Ia delay time distribution (DTD) with a power law: Ψ(t)ts . Under the approximation of a single-burst cluster formation redshift of zf = 3, our rate measurement in combination with lower-redshift cluster SN Ia rates constrains s = -1.41 +0.47-0.40, consistent with measurements of the DTD in the field. This measurement is generally consistent with expectations for the "double degenerate" scenario and inconsistent with some models for the "single degenerate" scenario predicting a steeper DTD at large delay times. We check for environmental dependence and the influence of younger stellar populations by calculating the rate specifically in cluster red-sequence galaxies and in morphologically early-type galaxies, finding results similar to the full cluster rate. Finally, the upper limit of one hostless cluster SN Ia detected in the survey implies that the fraction of stars in the intra-cluster medium is less than 0.47 (95% confidence), consistent with measurements at lower redshifts. © 2012. The American Astronomical Society. All rights reserved..