- Genazzani, Andrea;
- Panay, Nick;
- Simoncini, Tommaso;
- Depypere, Herman;
- Mueck, Alfred;
- Egarter, Christian;
- Biglia, Nicoletta;
- Fait, Tomas;
- Birkhaeuser, Martin;
- Skouby, Sven O;
- Brincat, Mark;
- Goldstein, Steven;
- Ruan, Xiangyan;
- Celis-Gonzales, Cuauhtémoc;
- Palacios, Santiago
Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones. This review focuses on one such non-hormonal option, namely, purified and specific cytoplasmic pollen extract, or PureCyTonin®. This extract has been evaluated in several preclinical and clinical studies, where it demonstrated its value as a safe and non-estrogenic alternative for menopause. This review presents the beneficial effects of PureCyTonin® in the treatment of menopausal symptoms (e.g. hot flushes) in healthy women, as well as in premenstrual syndrome. We discuss the mechanism of action of PureCyTonin®, an SSRI-'like' therapy. The lack of estrogenic effect demonstrated in preclinical studies suggests that PureCyTonin® may also be a suitable option for the management of menopausal symptoms in women with breast cancer.