Scarring alopecia, also known as cicatricial alopecia, is a group of hair loss disorders characterized by inflammatory destruction of hair follicles, leading to hair loss and scar tissue formation. Treating scarring alopecia is challenging due to the irreversible damage caused by the inflammatory process. Consequently, early intervention targeting inflammation is crucial for improving prognosis.1 Recently, several reports have emerged supporting the use of platelet-rich plasma (PRP) as a non-conventional therapy for scarring alopecia, suggesting its potential benefits in mitigating inflammation and halting disease progression. While there is a growing body of evidence demonstrating the efficacy and safety of PRP in nonscarring alopecia, such as androgenetic alopecia (AGA) and alopecia areata (AA), there remains a scarcity of evidence regarding the clinical benefits of PRP in scarring alopecias.2-7 In this study, we conducted a literature review exploring the effectiveness and safety of PRP in treating scarring alopecia. Eleven studies describing PRP treatment outcomes were identified. Overall, PRP demonstrated a positive impact, slowing disease progression with reduced signs of inflammation and no reported adverse effects. However, it is important to note that the evidence supporting the utility of PRP in scarring alopecias is currently limited to case reports. Therefore, immunomodulatory therapies should remain the mainstay therapy for scarring alopecias until further investigations are warranted. J Drugs Dermatol. 2024;23(12):1076-1082. doi:10.36849/JDD.7813.

Hypertrophic scars and keloids represent abnormal wound healing, manifesting as raised scars confined to or extending beyond the wound margin, respectively. Understanding the risk factors associated with these scarring types is crucial for prevention and management. Utilizing the TriNetX global health research network database, we analyzed the data of 6,249 patients with hypertrophic scars or keloids. We employed the ICD-10 code L91.0 for identification, generating a control cohort matched by age, sex, and race. Associations between scarring and race, ethnicity, and various comorbidities were quantified. The analysis revealed that hypertrophic scars and keloids were more commonly associated with Black/African American individuals (OR=1.74, P<0.01) and less so with White races and Hispanic ethnicity. Significant comorbidities associated with increased risk included scarring alopecia, rosacea, atopic dermatitis, and acne. Inadequate sample size limited analysis for conditions like vitiligo. The findings suggest a higher prevalence of these scars in Black/African American races, potentially linked to melanocyte-mediated fibroblast and extracellular matrix activities. A notable correlation with inflammatory conditions suggests shared cytokine pathways, highlighting IL-4 and IL-13 as therapeutic targets. The strong association between scarring alopecia and skin cancers may implicate chronic inflammation and treatment-related scarring. Limitations of the study include its retrospective design, possible misdiagnosis, and small sample sizes for certain comorbidities. J Drugs Dermatol. 2025;24(2):212-215. doi:10.36849/JDD.8401R1.